ArticlePediatric blood & cancer2013
Pregnancy after cancer: results from a prospective cohort study of cancer survivors.
Article in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pregnancy rate, maternal and neonatal outcomes among breast cancer survivors: A systematic review.Nursing open · 2023Pooled it
- Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review.Human reproduction update · 2022Pooled it
- IVF outcomes in cancer survivors: lower ovarian response and early embryo development but comparable success in frozen embryo transfer cycles - a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Anti-Mullerian Hormone and conception timing as predictors of live births in cancer patients using fertility preservation: a systematic review.Frontiers in oncology · 2025Review
- The use of fertility treatments among reproductive-aged women after cancer.Fertility and sterility · 2024Article
- Article
- Anti-Müllerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens.Bone marrow transplantation · 2020Article
- Differential Rates of Change in Measures of Ovarian Reserve in Young Cancer Survivors Across the Reproductive Lifespan.The Journal of clinical endocrinology and metabolism · 2019Article
- Chemotherapy-related damage to ovarian reserve in childhood cancer survivors: interpreting the evidence.Journal of assisted reproduction and genetics · 2019Article
- Article
- Ovarian and Uterine Functions in Female Survivors of Childhood Cancers.The oncologist · 2018Review
- Female cancer survivors exposed to alkylating-agent chemotherapy have unique reproductive hormone profiles.Fertility and sterility · 2016Article
- Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois.Journal of assisted reproduction and genetics · 2016Article
- Evidence to incorporate inclusive reproductive health measures in guidelines for childhood and adolescent cancer survivors.Journal of pediatric and adolescent gynecology · 2015Article
- Factors associated with pregnancy attempts among female young adult cancer survivors.Journal of cancer survivorship : research and practice · 2014Article
- Antimüllerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception.Fertility and sterility · 2014Article
- Preserving Fertility in Children and Adolescents with Cancer.Children (Basel, Switzerland) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFuture fertility is an important concern for many cancer survivors. Cancer therapies have been shown to adversely impact reproductive function. However, it is difficult to predict the extent to which reproductive dysfunction will occur. The purpose of this study was to compare measures of ovarian reserve (MOR) and pregnancy rates in young female cancer survivors and similar-aged controls. PROCEDURES: A prospective cohort study was conducted in a university-hospital setting. Participants were followed annually for a mean 25 months to assess reproductive history, the incidence of pregnancy, and MOR (serum follicle-stimulating hormone, luteinizing hormone, estradiol, inhibin B, anti-mullerian hormone (AMH), antral follicle counts and mean ovarian volume).
resultsEighty-four female survivors (average age 26, and 14 years post-treatment) and 98 similar-aged controls that were sexually active with men were included. At baseline, 27/84 survivors and 42/98 controls reported a prior pregnancy. Adjusted models showed that anti-mullerian hormone (AMH) and antral follicle count (AFC) were impaired in survivors with a prior pregnancy compared to controls with a prior pregnancy (P < 0.01, P = 0.03). During follow-up in 56 survivors and 74 controls, 19 pregnancies occurred in survivors and 18 in controls. Comparison of MOR between survivors who became pregnant and controls who became pregnant revealed that AMH and AFC were impaired in survivors (P < 0.05). Compared to survivors who did not become pregnant, survivors who did were older (P < 0.01) and more likely to be cohabitating (P < 0.01), but had similar MOR and exposure to alkylators (P = 0.34).
conclusionsSurvivors achieved pregnancy at a rate similar to controls despite impaired MOR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.