ArticleApplied and environmental microbiology2013
CelR, an ortholog of the diguanylate cyclase PleD of Caulobacter, regulates cellulose synthesis in Agrobacterium tumefaciens.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Comparative Transcriptome Analysis ofBiomolecules · 2022Article
- Characterization and genomic analysis of a diesel-degrading bacterium, Acinetobacter calcoaceticus CA16, isolated from Canadian soil.BMC biotechnology · 2020Article
- AmrZ and FleQ Co-regulate Cellulose Production inFrontiers in microbiology · 2019Article
- The cellulose synthase BcsA plays a role in interactions of Salmonella typhimurium with Acanthamoeba castellanii genotype T4.Parasitology research · 2018Article
- Ecological and evolutionary dynamics of a model facultative pathogen: Agrobacterium and crown gall disease of plants.Environmental microbiology · 2018Review
- TheMicrobiology (Reading, England) · 2017Article
- BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella enterica serovar Typhimurium.Microbial cell factories · 2016Article
- Article
- Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Establishing a Role for Bacterial Cellulose in Environmental Interactions: Lessons Learned from Diverse Biofilm-Producing Proteobacteria.Frontiers in microbiology · 2015Review
- A signaling pathway involving the diguanylate cyclase CelR and the response regulator DivK controls cellulose synthesis in Agrobacterium tumefaciens.Journal of bacteriology · 2014Article
- Responses to elevated c-di-GMP levels in mutualistic and pathogenic plant-interacting bacteria.PloS one · 2014Article
- Attachment of Agrobacterium to plant surfaces.Frontiers in plant science · 2014Review
- Mechanisms and regulation of surface interactions and biofilm formation in Agrobacterium.Frontiers in plant science · 2014Review
- Function and Regulation of Agrobacterium tumefaciens Cell Surface Structures that Promote Attachment.Current topics in microbiology and immunologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cellulose fibrils play a role in attachment of Agrobacterium tumefaciens to its plant host. While the genes for cellulose biosynthesis in the bacterium have been identified, little is known concerning the regulation of the process. The signal molecule cyclic di-GMP (c-di-GMP) has been linked to the regulation of exopolysaccharide biosynthesis in many bacterial species, including A. tumefaciens. In this study, we identified two putative diguanylate cyclase genes, celR (atu1297) and atu1060, that influence production of cellulose in A. tumefaciens. Overexpression of either gene resulted in increased cellulose production, while deletion of celR, but not atu1060, resulted in decreased cellulose biosynthesis. celR overexpression also affected other phenotypes, including biofilm formation, formation of a polar adhesion structure, plant surface attachment, and virulence, suggesting that the gene plays a role in regulating these processes. Analysis of celR and Δcel mutants allowed differentiation between phenotypes associated with cellulose production, such as biofilm formation, and phenotypes probably resulting from c-di-GMP signaling, which include polar adhesion, attachment to plant tissue, and virulence. Phylogenetic comparisons suggest that species containing both celR and celA, which encodes the catalytic subunit of cellulose synthase, adapted the CelR protein to regulate cellulose production while those that lack celA use CelR, called PleD, to regulate specific processes associated with polar localization and cell division.
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Registered trials
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