ArticleApplied and environmental microbiology2013
Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Real-world evidence on predictors of antimicrobial resistance among patients with chronic liver disease.Frontiers in medicine · 2026Article
- Hermetia illucens chitosan: indirect and direct antimicrobial activity of an innovative biopolymer for clinical and pharmaceutical applications.Applied microbiology and biotechnology · 2025Article
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- Arsenic efflux in Enterobacter cloacae RSN3 isolated from arsenic-rich soil.Folia microbiologica · 2021Article
- Genomic Characterization of Antimicrobial Resistance, Virulence, and Phylogeny of the GenusAntibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial resistance in chronic liver disease.Hepatology international · 2020Review
- Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy.Microorganisms · 2019Review
- Poverty and Community-Acquired Antimicrobial Resistance with Extended-Spectrum β-Lactamase-Producing Organisms, Hyderabad, India.Emerging infectious diseases · 2018Article
- Environmental factors influencing the development and spread of antibiotic resistance.FEMS microbiology reviews · 2018Review
- The Threat of Antimicrobial Resistance on the Human Microbiome.Microbial ecology · 2017Review
- Prevalence, Host Range, and Comparative Genomic Analysis of TemperateFrontiers in microbiology · 2017Article
- Antibiotic Resistance in India: Drivers and Opportunities for Action.PLoS medicine · 2016Article
- Limited Bacterial Diversity within a Treatment Plant Receiving Antibiotic-Containing Waste from Bulk Drug Production.PloS one · 2016Article
- Article
- In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.Antimicrobial agents and chemotherapy · 2015Article
- Pollution from drug manufacturing: review and perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.Frontiers in microbiology · 2014Article
- Article
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6 authors.
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Abstract
The external environment, particularly wastewater treatment plants (WWTPs), where environmental bacteria meet human commensals and pathogens in large numbers, has been highlighted as a potential breeding ground for antibiotic resistance. We have isolated the extensively drug-resistant Ochrobactrum intermedium CCUG 57381 from an Indian WWTP receiving industrial wastewater from pharmaceutical production contaminated with high levels of quinolones. Antibiotic susceptibility testing against 47 antibiotics showed that the strain was 4 to >500 times more resistant to sulfonamides, quinolones, tetracyclines, macrolides, and the aminoglycoside streptomycin than the type strain O. intermedium LMG 3301T. Whole-genome sequencing identified mutations in the Indian strain causing amino acid substitutions in the target enzymes of quinolones. We also characterized three acquired regions containing resistance genes to sulfonamides (sul1), tetracyclines [tet(G) and tetR], and chloramphenicol/florfenicol (floR). Furthermore, the Indian strain harbored acquired mechanisms for horizontal gene transfer, including a type I mating pair-forming system (MPFI), a MOBP relaxase, and insertion sequence transposons. Our results highlight that WWTPs serving antibiotic manufacturing may provide nearly ideal conditions for the recruitment of resistance genes into human commensal and pathogenic bacteria.
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