ArticleHuman brain mapping2014
The representation of oral fat texture in the human somatosensory cortex.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Mindfulness meditation modulates stress-eating and its neural correlates.Scientific reports · 2024Trial
- Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.Physiology & behavior · 2025Review
- A Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The psychological basis of reductions in food desire during satiety.Royal Society open science · 2023Article
- The role of viscosity in flavor preference: plasticity and interactions with taste.Chemical senses · 2022Article
- Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Studies of human twins reveal genetic variation that affects dietary fat perception.Chemical senses · 2020Article
- Extrinsic Factors Underlying Food Valuation in the Human Brain.Frontiers in behavioral neuroscience · 2020Review
- Neural activity in human ventromedial prefrontal cortex reflecting the intention to save reward.Social cognitive and affective neuroscience · 2019Article
- Functional Connectivity Within the Gustatory Network Is Altered by Fat Content and Oral Fat Sensitivity - A Pilot Study.Frontiers in neuroscience · 2019Article
- The Neuronal Encoding of Oral Fat by the Coefficient of Sliding Friction in the Cerebral Cortex and Amygdala.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Age differences in the brain mechanisms of good taste.NeuroImage · 2015Article
- Which foods may be addictive? The roles of processing, fat content, and glycemic load.PloS one · 2015Article
- Fat sensing and metabolic syndrome.Reviews in endocrine & metabolic disorders · 2014Review
- Is fat taste ready for primetime?Physiology & behavior · 2014Review
- A thermal window for yawning in humans: yawning as a brain cooling mechanism.Physiology & behavior · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How fat is sensed in the mouth and represented in the brain is important in relation to the pleasantness of food, appetite control, and the design of foods that reproduce the mouthfeel of fat yet have low energy content. We show that the human somatosensory cortex (SSC) is involved in oral fat processing via functional coupling to the orbitofrontal cortex (OFC), where the pleasantness of fat texture is represented. Using functional MRI, we found that activity in SSC was more strongly correlated with the OFC during the consumption of a high fat food with a pleasant (vanilla) flavor compared to a low fat food with the same flavor. This effect was not found in control analyses using high fat foods with a less pleasant flavor or pleasant-flavored low fat foods. SSC activity correlated with subjective ratings of fattiness, but not of texture pleasantness or flavor pleasantness, indicating a representation that is not involved in hedonic processing per se. Across subjects, the magnitude of OFC-SSC coupling explained inter-individual variation in texture pleasantness evaluations. These findings extend known SSC functions to a specific role in the processing of pleasant-flavored oral fat, and identify a neural mechanism potentially important in appetite, overeating, and obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.