ArticleMolecular carcinogenesis2015
Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.
Article in Molecular carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications.Molecular cancer · 2025Review
- Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia.World journal of stem cells · 2025Article
- JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis.Stem cell reports · 2024Article
- Network Pharmacology RevealsBiology · 2024Article
- Twist1 as a target for prevention of cutaneous squamous cell carcinoma.Molecular carcinogenesis · 2023Article
- MiR-149-5p promotes β-catenin-induced goat hair follicle stem cell differentiation.In vitro cellular & developmental biology. Animal · 2022Article
- HPV8 Reverses the Transcriptional Output in Lrig1 Positive Cells to Drive Skin Tumorigenesis.Cancers · 2022Article
- Essential Role of STAT3 Signaling in Hair Follicle Homeostasis.Frontiers in immunology · 2021Article
- STAT3 Partly Inhibits Cell ProliferationFrontiers in genetics · 2021Article
- IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation.Frontiers in cell and developmental biology · 2020Article
- Multiple-trait QTL mapping and genomic prediction for wool traits in sheep.Genetics, selection, evolution : GSE · 2017Article
- LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway.Oncotarget · 2016Article
- Twist1 regulates keratinocyte proliferation and skin tumor promotion.Molecular carcinogenesis · 2016Article
- Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.Oncotarget · 2015Article
- Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.Bioorganic & medicinal chemistry letters · 2015Article
- Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.Cancer prevention research (Philadelphia, Pa.) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo. BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates. There was a concomitant increase in the Lgr-6, Lrig-1, and Sca-1 populations in the Tg mice in contrast to the CD34 and Keratin-15 positive population. In addition, increased expression of c-myc, β-catenin, and epithelial-mesenchymal transition (EMT)-related genes as well as decreased expression of α6-integrin was observed in the hair follicles of Tg mice. Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes. The current data suggest that elevated Stat3 activity leads to depletion of hair follicle KSCs along with a concomitant increase of stem/progenitor cells above the bulge region. Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.