Evidence map›Paper›PMID 24038488›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2014

Mechanisms of muscle growth and atrophy in mammals and Drosophila.

Rosanna Piccirillo, Fabio Demontis, Norbert Perrimon, Alfred L Goldberg

Open access · bronzeAbstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 140 citations in OpenAlex.

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  16. Postsynaptic BMP signaling regulates myonuclear properties inbioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Muscle-fiber specific genetic manipulation ofFrontiers in physiology · 2024
    Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Rosanna PiccirilloDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts; Department of Oncology, IRCCS, Mario Negri Institute for Pharmacological Research, Milano, Italy.
Fabio Demontis
Norbert Perrimon
Alfred L Goldberg
Harvard University · USHoward Hughes Medical Institute · USMario Negri Institute for Pharmacological Research · ITSt. Jude Children's Research Hospital · US

Funding

Characterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2M
Molecular Mechanisms that Cause Muscle AtrophyR01AR055255 · NIAMS · HARVARD MEDICAL SCHOOL · PI GOLDBERG, ALFRED L · 2008 to 2012
$1.9M
Howard Hughes Medical InstituteNIAMS NIH HHS AR055255NIAMS NIH HHS R01 AR055255NIAMS NIH HHS R01 AR057352NIAMS NIH HHS R01AR057352
6 · The paper itself

Abstract

backgroundThe loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy.

resultsIn this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting.

conclusionsStudies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans.

Indexed as

Models, AnimalModels, BiologicalAnimalsDrosophilaInflammationMammalsMuscle DevelopmentMuscular AtrophyMyostatinNeurodegenerative DiseasesOxidative StressProteolysisSignal TransductionTranscription FactorsMyostatinTranscription Factorsanimal models of muscle wastingmuscle atrophyproteostasisskeletal muscle growth

Identifiers

PMID24038488
PMCPMC3980484
OpenAlexW1539373078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.