ArticleAnnals of neurology2014
Characterization of atypical language activation patterns in focal epilepsy.
Article in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
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Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of atypical language lateralization in focal epilepsy: A mega-analysis of fMRI evidence.Epilepsia · 2025Pooled it
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Quantitative Meta-Analyses: Lateralization of Memory Functions Before and After Surgery in Children with Temporal Lobe Epilepsy.Neuropsychology review · 2021Pooled it
- Naturalistic fMRI Language Mapping With Rotation Forest.Human brain mapping · 2026Article
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Contralateral language network integration predicts and protects against naming decline after temporal lobe resection.Epilepsia · 2026Article
- Atypical language lateralization and contralateral epileptiform activity in a right-handed patient with a left frontal cortical lesion: A multimodal presurgical evaluation.Surgical neurology international · 2026Article
- Clinical Application of Resting-State Functional MRI for Individualized Localization of Core Language Areas in Patients with Drug-Resistant Epilepsy: An Observational Study.Neuropsychiatric disease and treatment · 2026Article
- The upside of epilepsy: Theories of an evolutionary paradox.Epilepsia open · 2025Review
- Left parietal structural connectivity mediates typical and atypical language laterality in temporal lobe epilepsy.Epilepsia · 2025Article
- Neural (re)organisation of language and memory: implications for neuroplasticity and cognition.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- The neural basis of face pareidolia with human intracerebral recordings.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke.Scientific reports · 2024Article
- Surgical outcomes following resection in patients with language dominant posterior quadrant epilepsy.Epilepsy & behavior reports · 2024Article
- Language task-based fMRI analysis using machine learning and deep learning.Frontiers in radiology · 2024Article
- Design and methodology for a proof of mechanism study of individualized neuronavigated continuous Theta burst stimulation for auditory processing in adolescents with autism spectrum disorder.Frontiers in psychiatry · 2024Article
- Bilateral and asymmetrical localization of language function identified by the superselective infusion of propofol in an epilepsy patient with a mild malformation of cortical development: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- One right can make a left: sentence processing in the right hemisphere after perinatal stroke.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study.Scientific reports · 2023Article
28 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
objectiveFunctional magnetic resonance imaging is sensitive to the variation in language network patterns. Large populations are needed to rigorously assess atypical patterns, which, even in neurological populations, are a minority.
methodsWe studied 220 patients with focal epilepsy and 118 healthy volunteers who performed an auditory description decision task. We compared a data-driven hierarchical clustering approach to the commonly used a priori laterality index (LI) threshold (LI < 0.20 as atypical) to classify language patterns within frontal and temporal regions of interest. We explored (n = 128) whether IQ varied with different language activation patterns.
resultsThe rate of atypical language among healthy volunteers (2.5%) and patients (24.5%) agreed with previous studies; however, we found 6 patterns of atypical language: a symmetrically bilateral, 2 unilaterally crossed, and 3 right dominant patterns. There was high agreement between classification methods, yet the cluster analysis revealed novel correlations with clinical features. Beyond the established association of left-handedness, early seizure onset, and vascular pathology with atypical language, cluster analysis identified an association of handedness with frontal lateralization, early seizure onset with temporal lateralization, and left hemisphere focus with a unilateral right pattern. Intelligence quotient was not significantly different among patterns.
interpretationLanguage dominance is a continuum; however, our results demonstrate meaningful thresholds in classifying laterality. Atypical language patterns are less frequent but more variable than typical language patterns, posing challenges for accurate presurgical planning. Language dominance should be assessed on a regional rather than hemispheric basis, and clinical characteristics should inform evaluation of atypical language dominance. Reorganization of language is not uniformly detrimental to language functioning.
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