ArticleBMJ open2013
Impairment of brainstem implicit learning paradigms differentiates multiple system atrophy (MSA) from idiopathic Parkinson syndrome.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The blink reflex and its modulation - Part 1: Physiological mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Central nervous system physiology.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Review
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Authors and funding
5 authors.
Funding
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Abstract
objectivesLearning as measured by eyeblink classical conditioning is preserved in patients with idiopathic Parkinson's disease, but severely affected in patients with progressive supranuclear palsy. We here sought to clarify whether procedural learning is impaired in multiple system atrophy (MSA), and whether it may be helpful for the differentiation of parkinsonian syndromes.
designWe investigated learning using (1) eyeblink classical conditioning with a delay (interstimulus interval 0 ms) and a trace (600 ms) paradigm and (2) a serial reaction time task.
settingParticipants were recruited from academic research centres.
participants11 patients with MSA and 11 healthy controls.
resultsImplicit learning in eyeblink classical conditioning (acquisition of conditioned responses) as well as the serial reaction time task measures of implicit learning (reaction time change) are impaired in patients with MSA as compared with controls, whereas explicit learning as measured by the sequence recall of the serial reaction time task is relatively preserved. ANALYSIS: We hypothesise that the learning deficits of patients with MSA are due to lesions of cerebellar and connected brainstem areas.
conclusionsA retrospective synopsis of these novel data on patients with MSA and groups of patients with idiopathic Parkinson's disease and progressive supranuclear palsy studied earlier suggest that eyeblink classical conditioning may contribute to the early differentiation of atypical Parkinson syndromes from idiopathic Parkinson's disease. This hypothesis should be tested in a prospective trial.
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