ArticleLasers in surgery and medicine2013
Increased nanoparticle-loaded exogenous macrophage migration into the brain following PDT-induced blood-brain barrier disruption.
Article in Lasers in surgery and medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies.Acta neurochirurgica · 2024Review
- Regulation of macrophage activation by lactylation in lung disease.Frontiers in immunology · 2024Review
- Systematic Review of Photodynamic Therapy in Gliomas.Cancers · 2023Review
- Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma.Pharmaceutics · 2023Article
- Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience.Biomedical engineering online · 2023Review
- Photodynamic Opening of the Blood-Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors.Pharmaceutics · 2022Review
- Recent progress of macrophage vesicle-based drug delivery systems.Drug delivery and translational research · 2022Review
- Photothermal Therapy for the Treatment of Glioblastoma: Potential and Preclinical Challenges.Frontiers in oncology · 2020Review
- Optical properties of brain tissues at the different stages of glioma development in rats: pilot study.Biomedical optics express · 2019Article
- Functional Polymer Nanocarriers for Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Photodynamic opening of the blood-brain barrier to high weight molecules and liposomes through an optical clearing skull window.Biomedical optics express · 2018Article
- Photodynamic therapy mediated immune therapy of brain tumors.Neuroimmunology and neuroinflammation · 2018Article
- Photodynamic opening of blood-brain barrier.Biomedical optics express · 2017Article
- Cell Mediated Photothermal Therapy of Brain Tumors.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Review
- Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets.Stem cells international · 2016Review
- Nanoparticle-loaded macrophage-mediated photothermal therapy: potential for glioma treatment.Lasers in medical science · 2015Article
- Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene.Journal of neuro-oncology · 2014Article
- Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.Journal of biomedical optics · 2014Article
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Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectivePhotodynamic therapy (PDT)-induced disruption of the blood-brain barrier (BBB) has been investigated as a technique for the delivery of therapeutic agents to selective regions of the brain. The purpose of this study was to determine the effects of PDT on the migration of systemically administered exogenous macrophages (Ma) loaded with iron oxide nanoparticles in non-tumor bearing rats. MATERIALS AND
methodsA control group consisting of three Sprague-Dawley rats was injected with iron oxide-loaded rat alveolar Ma via jugular vein catheter while two animals were subjected to intracranial injection of iron oxide-loaded Ma. PDT-treated animals were injected with photosensitizer (AlPcS2a ; 1 mg/kg i.p.) followed by light irradiation (wavelength = 670 nm; light dose = 2.5 J) 48 hours later. Light irradiation was performed through the skull. Prior to light irradiation, iron oxide-loaded Ma were administered to each animal. Animals in all groups were imaged in a 7 Tesla (T) magnetic resonance (MR) imager to determine the extent of PDT-induced edema and to evaluate for the presence of iron oxide nanoparticles. Animals were sacrificed 7 days post-Ma administration and their brains analyzed for the presence of iron oxide using Perls staining.
resultsSignificant uptake of iron oxide nanoparticles by rat alveolar Ma was observed thus providing the rationale for their use as delivery vectors. Histopathological analyses failed to find evidence of iron oxide in normal rat brain. Accumulations of iron oxide-loaded Ma were observed in both MR images and histological sections of non-tumor bearing rat brain following PDT-induced disruption of the BBB.
conclusionsMR imaging was shown to be useful for localizing iron-oxide loaded Ma in rat brains. Exogenous Ma are incapable of traversing the normal BBB and therefore, the use of Ma as delivery vehicles into the brain requires selective disruption of the BBB.
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