ArticleLasers in surgery and medicine2013
Recovery of intrinsic fluorescence from single-point interstitial measurements for quantification of doxorubicin concentration.
Article in Lasers in surgery and medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Quantitative Fluorescence Imaging of Chemophototherapy Drug Pharmacokinetics Using Laparoscopic SFDI.International journal of molecular sciences · 2025Article
- Quantitative Fluorescence Imaging of Porphyrin Phospholipid Photobleaching and Light Activated Liposomal Doxorubicin Release Using Wide-field and Laparoscopic SFDI in an Ovarian Cancer Model.Research square · 2025Article
- Fluorescence and diffuse reflectance provide similar accuracy in recovering fluorophore concentration at short source-detector separations.Journal of modern optics · 2022Article
- Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe.Biomedical optics express · 2021Article
- A dual-channel endoscope for quantitative imaging, monitoring, and triggering of doxorubicin release from liposomes in living mice.Scientific reports · 2017Article
- Recovery of optical properties using interstitial cylindrical diffusers as source and detector fibers.Journal of biomedical optics · 2016Article
- Quantitative imaging of light-triggered doxorubicin release.Biomedical optics express · 2015Article
- Cylindrical diffuser axial detection profile is dependent on fiber design.Journal of biomedical optics · 2015Article
- Extraction of intrinsic fluorescence from single fiber fluorescence measurements on a turbid medium: experimental validation.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveWe developed a method for the recovery of intrinsic fluorescence from single-point measurements in highly scattering and absorbing samples without a priori knowledge of the sample optical properties. The goal of the study was to demonstrate accurate recovery of fluorophore concentration in samples with widely varying background optical properties, while simultaneously recovering the optical properties. MATERIALS AND
methodsTissue-simulating phantoms containing doxorubicin, MnTPPS, and Intralipid-20% were created, and fluorescence measurements were performed using a single isotropic probe. The resulting spectra were analyzed using a forward-adjoint fluorescence model in order to recover the fluorophore concentration and background optical properties.
resultsWe demonstrated recovery of doxorubicin concentration with a mean error of 11.8%. The concentration of the background absorber was recovered with an average error of 23.2% and the scattering spectrum was recovered with a mean error of 19.8%.
conclusionThis method will allow for the determination of local concentrations of fluorescent drugs, such as doxorubicin, from minimally invasive fluorescence measurements. This is particularly interesting in the context of transarterial chemoembolization (TACE) treatment of liver cancer.
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