ArticleRNA biology2013
Systematic study of subcellular localization of Arabidopsis PPR proteins confirms a massive targeting to organelles.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Chicken or egg? The evolutionary riddle of CMS and Rf in plants.Journal of integrative plant biology · 2026Article
- Mitochondrial-Nuclear Interactions, Co-Transcription, and Adaptive Evolution in Cytoplasmic Male Sterility.Plant, cell & environment · 2026Review
- A P-type pentatricopeptide repeat-containing protein interacts with the Japanese soil-borne wheat mosaic virus movement protein and modulates susceptibility to infection.The Journal of general virology · 2026Article
- Structural basis of the lobster carapace blue colour mediated by an HPR protein.bioRxiv : the preprint server for biology · 2026Article
- Pentatricopeptide repeat proteins in plants: Cellular functions, action mechanisms, and potential applications.Plant communications · 2025Review
- Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein.Nucleic acids research · 2024Article
- Transcriptome-wide Identification of Nine Tandem Repeat Protein Families in Roselle (Tropical life sciences research · 2024Article
- The MKK3 module integrates nitrate and light signals to modulate secondary dormancy inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Temperature and light reverse the fertility of rice P/TGMS line ostms19 via reactive oxygen species homeostasis.Plant biotechnology journal · 2024Article
- Landscape genomics reveals genetic signals of environmental adaptation of African wild eggplants.Ecology and evolution · 2024Article
- Involvement of a rice mutation in storage protein biogenesis in endosperm and its genomic location.Planta · 2024Article
- Identification of domains in Plasmodium falciparum proteins of unknown function using DALI search on AlphaFold predictions.Scientific reports · 2024Article
- Two large inversions seriously suppress recombination and are essential for key genotype fixation in cabbage (Horticulture research · 2024Article
- Article
- PPR596 Is Required forInternational journal of molecular sciences · 2024Article
- Characterization of theGenes · 2023Article
- Coordinated regulation of the mitochondrial retrograde response by circadian clock regulators and ANAC017.Plant communications · 2023Article
- Multi-locus genome-wide association study of fusarium head blight in relation to days to anthesis and plant height in a spring wheat association panel.Frontiers in plant science · 2023Article
- Biased gene expression reveals the contribution of subgenome to altitude adaptation in allopolyploidEcology and evolution · 2022Article
- An Overview of Pentatricopeptide Repeat (PPR) Proteins in the MossPlants (Basel, Switzerland) · 2022Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Four hundred and fifty-eight genes coding for PentatricoPeptide Repeat (PPR) proteins are annotated in the Arabidopsis thaliana genome. Over the past 10 years, numerous reports have shown that many of these proteins function in organelles to target specific transcripts and are involved in post-transcriptional regulation. Therefore, they are thought to be important players in the coordination between nuclear and organelle genome expression. Only four of these proteins have been described to be addressed outside organelles, indicating that some PPRs could function in post-transcriptional regulations of nuclear genes. In this work, we updated and improved our current knowledge on the localization of PPR proteins of Arabidopsis within the plant cell. We particularly investigated the subcellular localization of 166 PPR proteins whose targeting predictions were ambiguous, using a combination of high-throughput cloning and microscopy. Through systematic localization experiments and data integration, we confirmed that PPR proteins are largely targeted to organelles and showed that dual targeting to both the mitochondria and plastid occurs more frequently than expected. These results allow us to speculate that dual-targeted PPR proteins could be important for the fine coordination of gene expressions in both organelles.
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