Evidence map›Paper›PMID 24037299›Full record

Trial reportEuropean radiology2014

Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn's disease assessment with histopathology of surgical specimens.

Jeroen A W Tielbeek, Manon L W Ziech, Zhang Li, Cristina Lavini, Shandra Bipat, Willem A Bemelman, Joris J T H Roelofs, Cyriel Y Ponsioen, Frans M Vos, Jaap Stoker

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 6 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 6 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Article
  10. Crohn Disease Strictures: Multimodality Imaging to Identify Imaging Biomarkers.Radiographics : a review publication of the Radiological Society of North America, Inc · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Comprehensive review and update of stricturing Crohn's disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  18. Review
  19. How to Evaluate Fibrosis in IBD?Diagnostics (Basel, Switzerland) · 2023
    Review
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeroen A W TielbeekAcademic Medical Center, Department of Radiology, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands, j.a.w.tielbeek@amc.uva.nl.
Manon L W Ziech
Zhang Li
Cristina Lavini
Shandra Bipat
Willem A Bemelman
Joris J T H Roelofs
Cyriel Y Ponsioen
Frans M Vos
Jaap Stoker
Academic Medical Center · NLUniversity of Amsterdam · NLDelft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo prospectively compare conventional MRI sequences, dynamic contrast enhanced (DCE) MRI and diffusion weighted imaging (DWI) with histopathology of surgical specimens in Crohn's disease.

methods3-T MR enterography was performed in consecutive Crohn's disease patients scheduled for surgery within 4 weeks. One to four sections of interest per patient were chosen for analysis. Evaluated parameters included mural thickness, T1 ratio, T2 ratio; on DCE-MRI maximum enhancement (ME), initial slope of increase (ISI), time-to-peak (TTP); and on DWI apparent diffusion coefficient (ADC). These were compared with location-matched histopathological grading of inflammation (AIS) and fibrosis (FS) using Spearman correlation, Kruskal-Wallis and Chi-squared tests.

resultsTwenty patients (mean age 38 years, 12 female) were included and 50 sections (35 terminal ileum, 11 ascending colon, 2 transverse colon, 2 descending colon) were matched to AIS and FS. Mural thickness, T1 ratio, T2 ratio, ME and ISI correlated significantly with AIS, with moderate correlation (r = 0.634, 0.392, 0.485, 0.509, 0.525, respectively; all P < 0.05). Mural thickness, T1 ratio, T2 ratio, ME, ISI and ADC correlated significantly with FS (all P < 0.05).

conclusionsQuantitative parameters from conventional, DCE-MRI and DWI sequences correlate with histopathological scores of surgical specimens. DCE-MRI and DWI parameters provide additional information. KEY POINTS: • Conventional MR enterography can be used to assess Crohn's disease activity. • Several MRI parameters correlate with inflammation and fibrosis scores from histopathology. • Dynamic contrast enhanced imaging and diffusion weighted imaging give additional information. • Quantitative MRI parameters can be used as biomarkers to evaluate Crohn's disease activity.

Indexed as

AdultAgedBiopsyColonContrast MediaCrohn DiseaseDiffusion Magnetic Resonance ImagingFemaleHumansIleumMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesYoung AdultContrast Media

Identifiers

PMID24037299
OpenAlexW2166130512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.