Evidence map›Paper›PMID 24037210›Full record

ArticleAIDS (London, England)2013

Association of self-reported race with AIDS death in continuous HAART users in a cohort of HIV-infected women in the United States.

Kerry Murphy, Donald R Hoover, Qiuhu Shi, Mardge Cohen, Monica Gandhi, Elizabeth T Golub, Deborah R Gustafson, Celeste Leigh Pearce, Mary Young, Kathryn Anastos

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mental health, substance use, and risky sexual behaviors among women living with HIV.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Depressive Symptoms and Engagement in Human Immunodeficiency Virus Care Following Antiretroviral Therapy Initiation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  12. Cumulative Burden of Depression and All-Cause Mortality in Women Living With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  13. Article
  14. Article
  15. Observational
  16. Cohort Profile: The Women's Interagency HIV Study (WIHS).International journal of epidemiology · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Correlates of Antiretroviral Therapy Adherence among HIV-Infected Older Adults.Journal of the International Association of Providers of AIDS Care · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 2 countries.

Kerry MurphyaAlbert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York bRutgers University, Piscataway, New Jersey cSchool of Health Sciences and Practice/New York Medical College, Valhalla, New York dCook County Health and Hospitals System eRush University, Chicago, Illinois fUniversity of California San Francisco, San Francisco, California gJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland hState University of New York/Downstate Medical Center, Brooklyn, New York, USA iUniversity of Gothenburg, Gothenburg, Sweden jUniversity of Southern California, Los Angeles, California kGeorgetown University, Washington, District of Columbia, USA.
Donald R Hoover
Qiuhu Shi
Mardge Cohen
Monica Gandhi
Elizabeth T Golub
Deborah R Gustafson
Celeste Leigh Pearce
Mary Young
Kathryn Anastos
Georgetown University · USGTx (United States) · USJohns Hopkins University · USMontefiore Medical Center · USNew York Medical College · USRush University · USRutgers, The State University of New Jersey · USUniversity of California, San Francisco · USUniversity of Gothenburg · SEUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Training in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6M
NCRR NIH HHS UL1 RR024131NIAID NIH HHS P30 AI027763NIAID NIH HHS T32 AI007501NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01-AI-31834NIAID NIH HHS U01-AI-34989NIAID NIH HHS U01-AI-34993NIAID NIH HHS U01-AI-34994NIAID NIH HHS U01-AI-35004NIAID NIH HHS U01-AI-42590NICHD NIH HHS U01-HD-32632
6 · The paper itself

Abstract

objectiveTo assess the association of race with clinical outcomes in HIV-positive women on continuous HAART.

designProspective study that enrolled women from 1994 to 1995 and 2001 to 2002.

settingWomen's Interagency HIV Study, a community-based cohort in five US cities.

participantsOne thousand, four hundred and seventy-one HIV-positive continuous HAART users.

main outcome measuresTimes to AIDS and non-AIDS death and incident AIDS-defining illness (ADI) after HAART initiation.

resultsIn adjusted analyses, black vs. white women had higher rates of AIDS death [adjusted hazard ratio (aHR) 2.14, 95% confidence interval (CI) 1.30, 3.50; P = 0.003] and incident ADI (aHR 1.58, 95% CI 1.08, 2.32; P = 0.02), but not non-AIDS death (aHR 0.91, 95% CI 0.59, 1.39; P = 0.65). Cumulative AIDS death incidence at 10 years was 17.3 and 8.3% for black and white women, respectively. Other significant independent pre-HAART predictors of AIDS death included peak viral load (aHR 1.70 per log₁₀, 95% CI 1.34, 2.16; P < 0.001), nadir CD4⁺ cell count (aHR 0.65 per 100 cells/μl, 95% CI 0.56, 0.76; P < 0.001), depressive symptoms by Center for Epidemiology Studies Depression score at least 16 (aHR 2.10, 95% CI 1.51, 2.92; P < 0.001), hepatitis C virus infection (aHR 1.57, 95% CI 1.02, 2.40; P = 0.04), and HIV acquisition via transfusion (aHR 2.33, 95% CI 1.21, 4.49; P = 0.01). In models with time-updated HAART adherence, association of race with AIDS death remained statistically significant (aHR 3.09, 95% CI 1.38, 6.93; P = 0.006).

conclusionIn continuous HAART-using women, black women more rapidly died from AIDS or experienced incident ADI than their white counterparts after adjusting for confounders. Future studies examining behavioral and biologic factors in these women may further the understanding of HAART prognosis.

Indexed as

Acquired Immunodeficiency SyndromeAdultAntiretroviral Therapy, Highly ActiveBlack or African AmericanBlack PeopleFemaleHIV InfectionsHumansPrognosisProspective StudiesRisk FactorsSurvival RateUnited StatesWhite People

Identifiers

PMID24037210
PMCPMC3815041
OpenAlexW1996413705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.