ArticleMolecular imaging and biology2014
Comparison of 4D-microSPECT and microCT for murine cardiac function.
Article in Molecular imaging and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Probing Early Myocardial Remodeling in Response to a High-Fat Diet in Mice by Evaluation of Extracellular Volume Fraction Using 4D Retrospectively Gated Micro-CT Imaging.Molecular imaging and biology · 2026Article
- Can micro-CT distinguish between solid lung tumors? A comparative evaluation including solid adenocarcinoma, non-keratinizing squamous cell carcinoma, and carcinoid tumor.Journal of pathology and translational medicine · 2026Article
- Comparative Analysis of Ultrasonography and MicroCT Imaging for Organ Size Evaluation in Mice.Journal of imaging · 2025Article
- 3D visualization and printing: An "Anatomical Engineering" trend revealing underlying morphology via innovation and reconstruction towards future of veterinary anatomy.Anatomical science international · 2024Review
- Micro-CT for Biological and Biomedical Studies: A Comparison of Imaging Techniques.Journal of imaging · 2021Review
- Validating in vivo hyperpolarizedMagnetic resonance in medicine · 2021Article
- Accuracy of cardiac functional parameters measured from gated radionuclide myocardial perfusion imaging in mice.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Evaluation of cardiac function by nuclear imaging in preclinical studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources.Scientific reports · 2019Article
- Effect of different anesthetic agents on left ventricular systolic function assessed by echocardiography in hamsters.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography.Journal of visualized experiments : JoVE · 2016Article
- Remodeling of alveolar septa after murine pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform.EJNMMI research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe objective of this study was to compare a new generation of four-dimensional micro-single photon emission computed tomography (microSPECT) with microCT for the quantitative in vivo assessment of murine cardiac function. PROCEDURES: Four-dimensional isotropic cardiac images were acquired from anesthetized normal C57BL/6 mice with either microSPECT (n = 6) or microCT (n = 6). One additional mouse with myocardial infarction (MI) was scanned with both modalities. Prior to imaging, mice were injected with either technetium tetrofosmin for microSPECT or a liposomal blood pool contrast agent for microCT. Segmentation of the left ventricle (LV) was performed using Vitrea (Vital Images) software, to derive global and regional function.
resultsMeasures of global LV function between microSPECT and microCT groups were comparable (e.g., ejection fraction = 71 ± 6 % microSPECT and 68 ± 4 % microCT). Regional functional indices (wall motion, wall thickening, regional ejection fraction) were also similar for the two modalities. In the mouse with MI, microSPECT identified a large perfusion defect that was not evident with microCT.
conclusionsDespite lower spatial resolution, microSPECT was comparable to microCT in the quantitative evaluation of cardiac function. MicroSPECT offers an advantage over microCT in the ability to evaluate simultaneously myocardial radiotracer distribution and function, simultaneously. MicroSPECT should be considered as an alternative to microCT and magnetic resonance for preclinical cardiac imaging in the mouse.
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