ArticlePediatric nephrology (Berlin, Germany)2014
Increasing frequency of acute kidney injury amongst children hospitalized with nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Development and external validation of a machine learning-based predictive model for acute kidney injury in hospitalized children with idiopathic nephrotic syndrome.BMC medical informatics and decision making · 2025Article
- Risk factors and renal outcomes of AKI in children with secondary steroid-resistant nephrotic syndrome.Renal failure · 2024Article
- Plasma D-asparagine and the D/L-serine ratio reflect chronic kidney diseases in children regardless of physique.Amino acids · 2024Article
- Clinical Profile and Outcomes of Nephrotic Syndrome With Acute Kidney Injury in Adults: A Prospective Cohort Study.Cureus · 2023Article
- Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review.International journal of nephrology and renovascular disease · 2022Article
- Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome.Renal failure · 2021Observational
- Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2019Article
- Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities.International journal of nephrology and renovascular disease · 2019Review
- Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness.Sudanese journal of paediatrics · 2019Article
- Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.Kidney research and clinical practice · 2018Article
- Acute kidney injury in children with nephrotic syndrome: a single-center study.Clinical kidney journal · 2018Article
- Acute Kidney Injury in Nephrotic Syndrome.Frontiers in pediatrics · 2018Review
- Acute kidney injury in idiopathic nephrotic syndrome of childhood is a major risk factor for the development of chronic kidney disease.Renal failure · 2017Article
- The Genetics of Nephrotic Syndrome.Journal of pediatric genetics · 2016Review
- AKI in Children Hospitalized with Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Healthcare burden of venous thromboembolism in childhood chronic renal diseases.Pediatric nephrology (Berlin, Germany) · 2015Article
- Pathophysiology, Evaluation, and Management of Edema in Childhood Nephrotic Syndrome.Frontiers in pediatrics · 2015Review
- Long-Term Outcomes in Children with Steroid-Resistant Nephrotic Syndrome Treated with Calcineurin Inhibitors.Frontiers in pediatrics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundNephrotic syndrome (NS) is among the most common kidney diseases seen in children. The major complications of NS include infection, acute kidney injury (AKI), and thromboembolism (TE). The objective of this study was to analyze long-term trends in the epidemiology of major complications of pediatric NS.
methodsWe used the Healthcare Cost and Utilization Project Kids' Inpatient Database for the years 2000-2009 to perform an analysis of U.S. hospitalizations of children diagnosed with NS with or without infection, AKI or TE.
resultsThe frequency of NS hospitalizations complicated by AKI increased by 158 % between 2000 and 2009 (p < 0.001). The frequency of NS hospitalizations with infection and TE remained stable overall. Pneumonia was the most common infectious complication while peritonitis decreased by 50 % (p < 0.001). Importantly, development of any of these major complications of NS resulted in ∼2-3-fold increases in both hospital charges and length of stay.
conclusionsIt is concerning that the frequency of AKI in children hospitalized with NS has more than doubled in the past decade. Strategies to prevent or initiate earlier treatments for complications of NS could have a major impact on both morbidity and health care expenses.
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