ArticleUrolithiasis2013
Alteration of urinary macromolecules by adsorption on surfaces, probably an important factor in urolithiasis.
Article in Urolithiasis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Prevention of Calcium Nephrolithiasis: The Influence of Diuresis on Calcium Oxalate Crystallization in Urine.Advances in preventive medicine · 2019Review
- The paradoxical role of urinary macromolecules in the aggregation of calcium oxalate: a further plea to increase diuresis in stone metaphylaxis.Urolithiasis · 2016Article
- From crystalluria to kidney stones, some physicochemical aspects of calcium nephrolithiasis.World journal of nephrology · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To get information on the consequences of adsorption of urinary macromolecules (UMs) on crystals, Ca phosphate (CaP) precipitation was performed in urine of 15 stone patients and 15 controls. In solutions of dissolved precipitates (DPU), Ca oxalate (CaOx) crystallization and aggregation (AGN) of latex beads were spectrophotometrically studied and compared to results obtained in urine and in UMs isolated by hemofilter dialysis (HD). Tests were repeated with a 20 μg/mL albumin solution (AS). Inhibition of CaOx growth and AGN was significantly reduced in DPU as well as in HD. Furthermore, DPU and HD showed an AGN of latex beads which in patients was more pronounced than in controls. Identical effects observed in DPU and HD can be explained by temporary high concentrations of UMs by adsorption on surfaces favoring self AGN. Temporary adsorption of AS on CaP produced polymers of a limited size, significantly reduced the inhibition of CaOx AGN and accelerated latex AGN. In DPU, AGN of latex beads occurred despite a surface potential of -37 mV, which within short distances produces areas of massive electrostatic repulsion and normally inhibits AGN. Such areas might be bridged by self-aggregated UMs. The retardation of CaOx AGN measured in DPU could be decisive whether during crystalluria crystals are washed out from the kidney by diuresis or are attached to kidney calcifications or pre-existing stones.
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