ArticleNature genetics2013
Dampening of expression oscillations by synchronous regulation of a microRNA and its target.
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Caenorhabditis elegans single-cell developmental data reveals multi-frequency oscillation in gene activation.Bioinformatics (Oxford, England) · 2020Pooled it
- Review
- FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits thebioRxiv : the preprint server for biology · 2026Article
- A molecular timer couples organism-wide temporal identity to developmental checkpoints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation.Molecular biology and evolution · 2026Article
- A developmental timer coordinates organism-wide microRNA transcription.bioRxiv : the preprint server for biology · 2026Article
- The interplay betweeniScience · 2025Article
- Systematic identification of oscillatory gene expression in single cell types.bioRxiv : the preprint server for biology · 2025Article
- The advantage of periodic over constant signalling in microRNA-mediated regulation.Nucleic acids research · 2025Article
- FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration inbioRxiv : the preprint server for biology · 2025Article
- Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.bioRxiv : the preprint server for biology · 2025Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans.PLoS genetics · 2025Article
- Out-of-Equilibrium ceRNA Crosstalk.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Out-of-Equilibrium ceRNA Crosstalk.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage inbioRxiv : the preprint server for biology · 2024Article
- The NHR-23-regulated putative protease inhibitorbioRxiv : the preprint server for biology · 2024Article
- Caenorhabditis elegans Hedgehog-related proteins are tissue- and substructure-specific components of the cuticle and precuticle.Genetics · 2024Article
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNAeLife · 2024Article
- The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.G3 (Bethesda, Md.) · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The complexity of multicellular organisms requires precise spatiotemporal regulation of gene expression during development. We find that in the nematode Caenorhabditis elegans approximately 2,000 transcripts undergo expression oscillations synchronized with larval transitions while thousands of genes are expressed in temporal gradients, similar to known timing regulators. By counting transcripts in individual worms, we show that pulsatile expression of the microRNA (miRNA) lin-4 maintains the temporal gradient of its target lin-14 by dampening its expression oscillations. Our results demonstrate that this insulation is optimal when pulsatile expression of the miRNA and its target is synchronous. We propose that such a miRNA-mediated incoherent feed-forward loop is a potent filter that prevents the propagation of potentially deleterious fluctuations in gene expression during the development of an organism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.