Evidence map›Paper›PMID 24036842›Full record

Trial reportObesity surgery2014

Systemic lidocaine to improve quality of recovery after laparoscopic bariatric surgery: a randomized double-blinded placebo-controlled trial.

Gildasio S De Oliveira, Kenyon Duncan, Paul Fitzgerald, Antoun Nader, Robert W Gould, Robert J McCarthy

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03667001 phase3completednot on this mapstarted 2018, after this paper: background citation

Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery: Prospective, Randomized, Double-blinded, Placebo Controlled, Mono-Center Study

TypeinterventionalSponsorMiodrag Filipovic, Prof. Dr. med.Ran2018 to 2021Enrolled140ConditionsPain, PostoperativeArmsLidocaine Hydrochloride, Saline Solution
NCT04524130 phase4completednot on this mapstarted 2021, after this paper: background citation

The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorMahidol UniversityRan2021 to 2025Enrolled87ConditionsLaparoscopic Bariatric SurgeryArmsLidocaine Hydrochloride, Ketamine, Placebo
NCT05153785 phase2 / phase3completednot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study

TypeinterventionalSponsorLund University HospitalRan2021 to 2025Enrolled124ConditionsLiver Metastases, Liver Cancer, Postoperative Pain, Opioid UseArmsLidocaine, Normal saline
NCT06785987 phase4enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Continuous Lidocaine Infusion in Thyroid Surgery Using Intraoperative Neurophysiological Monitoring

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2024 to 2027Enrolled100ConditionsThyroid Disease, Thyroid Surgery, Lidocaine InfusionArmsContinuous Lidocaine Infusion, intermittent fentanyl infusion, Continuous remifentanil Infusion
NCT07073846 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled104ConditionsMorbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative AnalgesiaArmsIntravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia, 0.9 % Saline Placebo + Standard Anesthesia
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gildasio S De OliveiraDepartment of Anesthesiology, Northwestern University, Chicago, IL, USA, g-jr@northwestern.edu.
Kenyon Duncan
Paul Fitzgerald
Antoun Nader
Robert W Gould
Robert J McCarthy
Northwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew multimodal strategies to minimize postoperative pain and improve recovery have been examined in morbidly obese patients undergoing laparoscopic bariatric surgery. The main objective of this study was to evaluate the effect of systemic intraoperative lidocaine on postoperative quality of recovery when compared to saline.

methodsThe study was a prospective randomized, double-blinded placebo-controlled clinical trial. Subjects undergoing laparoscopic bariatric surgery were randomized to receive lidocaine (1.5 mg/kg bolus followed by a 2 mg/kg/h infusion until the end of the surgical procedure) or the same volume of saline. The primary outcome was the quality of recovery 40 questionnaire at 24 h after surgery.

resultsFifty-one subjects were recruited and 50 completed the study. The global QoR-40 scores at 24 h were greater in the lidocaine group median (IQR) of 165 (151 to 170) compared to the saline group, median (IQR) of 146 (130 to 169), P = 0.01. Total 24 h opioid consumption was lower in the lidocaine group, median (IQR) of 26 (19 to 46) mg IV morphine equivalents compared to the saline group, median (IQR) of 36 (24 to 65) mg IV morphine equivalents, P = 0.03. Linear regression demonstrated an inverse relationship between the total 24 h opioid consumption (IV morphine equivalents) and 24 h postoperative quality of recovery (P < 0.0001).

conclusionsSystemic lidocaine improves postoperative quality of recovery in patients undergoing laparoscopic bariatric surgery. Patients who received lidocaine had a lower opioid consumption which translated to a better quality of recovery.

Indexed as

Bariatric SurgeryLaparoscopyAdultAnalgesics, OpioidAnesthetics, LocalDouble-Blind MethodFemaleHumansLidocaineMaleMiddle AgedObesity, MorbidPain MeasurementPostoperative PainProspective StudiesRecovery of FunctionAnalgesics, OpioidAnesthetics, LocalLidocaine

Identifiers

PMID24036842
OpenAlexW1984738922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.