ArticleNeuroscience letters2013
Blockade of B2 receptors attenuates the responses of group III afferents to static contraction.
Article in Neuroscience letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats.The Journal of physiology · 2025Article
- Bradykinin 2 receptors contribute to the exaggerated exercise pressor reflex in a rat model of simulated peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Cardiovascular Responses During Light-intensity Aerobic Exercise with Varying Levels of Limb Occlusion Pressures.International journal of exercise science · 2023Article
- KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Effects of bradykinin on voltage-gated KThe Journal of physiology · 2021Article
- KJournal of neurophysiology · 2021Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Sympathetic Nerve Control of Blood Pressure Response during Exercise in Peripheral Artery Disease and Current Application of Experimental Disease Models.American journal of biomedical science & research · 2020Article
- Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.Internal medicine review (Washington, D.C. : Online) · 2016Article
- The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats.The Journal of physiology · 2016Article
- The exercise pressor reflex and peripheral artery disease.Autonomic neuroscience : basic & clinical · 2015Review
- TRPA1 mediates amplified sympathetic responsiveness to activation of metabolically sensitive muscle afferents in rats with femoral artery occlusion.Frontiers in physiology · 2015Article
- Nerve Growth Factor, Muscle Afferent Receptors and Autonomic Responsiveness with Femoral Artery Occlusion.Journal of modern physiological research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence has been presented demonstrating that group III mechanoreceptors comprise an important part of the sensory arm of the exercise pressor reflex, which in turn functions to increase arterial blood flow to contracting skeletal muscles. Although group III afferents are stimulated by mechanical distortion of their receptive fields, they are also stimulated by bradykinin, which is produced by skeletal muscle when it contracts. Moreover, blockade of B (bradykinin)2 receptors has been shown to decrease the magnitude of the exercise pressor reflex. Nevertheless, the effect of blockade of B2 receptors on responses of group III afferents to contraction is not known. We therefore determined the effect of B2 receptor blockade with HOE 140 (40μg/kg) on the responses to both static and intermittent contraction of group III afferents with endings in the triceps surae muscle of decerebrated unanesthetized cats. We found that HOE 140 significantly attenuated (P=0.04) the responses of 14 group III afferents to static contraction, but did not significantly attenuate (P=0.16) the responses of 16 group III afferents to intermittent contraction. The attenuation induced by HOE 140 was present throughout the static contraction period, and led us to speculate that blockade of B2 receptors on the endings of group III afferents decreased their sensitivity to mechanical events occurring in the working muscles.
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