ArticleMolecular and cellular biology1990
The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 23 citations in OpenAlex.
- Nonreplicative functions of the origin recognition complex.Nucleus (Austin, Tex.) · 2018Review
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2012Review
- Ume6 is required for the MATa/MATalpha cellular identity and transcriptional silencing in Kluyveromyces lactis.Genetics · 2010Article
- Analyses of SUM1-1-mediated long-range repression.Genetics · 2006Article
- Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression.Genes & development · 2005Article
- Role of Ndt80, Sum1, and Swe1 as targets of the meiotic recombination checkpoint that control exit from pachytene and spore formation in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Regulation of the premiddle and middle phases of expression of the NDT80 gene during sporulation of Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Nucleic acids research · 2002Review
- A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex.Molecular and cellular biology · 2001Article
- Conversion of a gene-specific repressor to a regional silencer.Genes & development · 2001Article
- Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.Genetics · 1998Article
- SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability.Molecular and cellular biology · 1996Article
- Silencers, silencing, and heritable transcriptional states.Microbiological reviews · 1992Review
- Article
- Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.Molecular and cellular biology · 1991Article
- Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The silent mating-type genes (HML and HMR) of Saccharomyces cerevisiae are kept under negative transcriptional control by the trans-acting products of the four MAR/SIR loci. MAR/SIR gene mutations result in the simultaneous derepression of HML and HMR gene expression. The sum1-1 mutation was previously identified as an extragenic suppressor of mutations in MAR1 (SIR2) and MAR2 (SIR3). As assayed genetically, sum1-1 is capable of restoring repression of silent mating-type information in cells containing mar1 or mar2 null mutations. We show here that the mating-type phenotype associated with sum1-1 results from a dramatic reduction in the steady-state level of HML and HMR gene transcripts. At the same time, the sum1-1 mutation has no significant effect on the level of each of the four MAR/SIR mRNAs.
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