ArticleJournal of molecular biology2014
The plant host can affect the encapsidation of brome mosaic virus (BMV) RNA: BMV virions are surprisingly heterogeneous.
Article in Journal of molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Structural insights into dynamics of the BMV TLS aminoacylation.Nature communications · 2025Article
- Characterization of Variant RNAs Encapsidated during Bromovirus Infection by High-Throughput Sequencing.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Modulation of Capsid Dynamics in Bromoviruses by the Host and Heterologous Viral Replicase.Journal of virology · 2023Article
- Variability among the Isolates of Broad Bean Mottle Virus and Encapsidation of Host RNAs.Pathogens (Basel, Switzerland) · 2022Article
- Compositional complementarity between genomic RNA and coat proteins in positive-sense single-stranded RNA viruses.Nucleic acids research · 2022Article
- Genome organization and interaction with capsid protein in a multipartite RNA virus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Unravelling the Stability and Capsid Dynamics of the Three Virions of Brome Mosaic Virus Assembled AutonomouslyJournal of virology · 2020Article
- BMV Propagation, Extraction and Purification Using Chromatographic Methods.Bio-protocol · 2018Article
- The intrinsically disordered N-terminal arm of the brome mosaic virus coat protein specifically recognizes the RNA motif that directs the initiation of viral RNA replication.Nucleic acids research · 2018Article
- Electron Microscopy Methods for Virus Diagnosis and High Resolution Analysis of Viruses.Frontiers in microbiology · 2018Review
- Within-host Evolution of Segments Ratio for the Tripartite Genome of Alfalfa Mosaic Virus.Scientific reports · 2017Article
- The Strange Lifestyle of Multipartite Viruses.PLoS pathogens · 2016Review
- Phosphorylation of the Brome Mosaic Virus Capsid Regulates the Timing of Viral Infection.Journal of virology · 2016Article
- Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2.Journal of molecular biology · 2016Article
- Potato Virus M-Like Nanoparticles: Construction and Characterization.Molecular biotechnology · 2015Article
- Heterogeneous Ribonucleoprotein K (hnRNP K) Binds miR-122, a Mature Liver-Specific MicroRNA Required for Hepatitis C Virus Replication.Molecular & cellular proteomics : MCP · 2015Article
- Asymmetric genome organization in an RNA virus revealed via graph-theoretical analysis of tomographic data.PLoS computational biology · 2015Article
- Comparative Study of Non-Enveloped Icosahedral Viruses Size.PloS one · 2015Article
- Mapping RNA Sequences that Contact Viral Capsid Proteins in Virions.Bio-protocol · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brome mosaic virus (BMV) packages its genomic and subgenomic RNAs into three separate viral particles. BMV purified from barley, wheat, and tobacco have distinct relative abundances of the encapsidated RNAs. We seek to identify the basis for the host-dependent differences in viral RNA encapsidation. Sequencing of the viral RNAs revealed recombination events in the 3' untranslated region of RNA1 of BMV purified from barley and wheat, but not from tobacco. However, the relative amounts of the BMV RNAs that accumulated in barley and wheat are similar and RNA accumulation is not sufficient to account for the difference in RNA encapsidation. Virions purified from barley and wheat were found to differ in their isoelectric points, resistance to proteolysis, and contacts between the capsid residues and the RNA. Mass spectrometric analyses revealed that virions from the three hosts had different post-translational modifications that should impact the physiochemical properties of the virions. Another major source of variation in RNA encapsidation was due to the purification of BMV particles to homogeneity. Highly enriched BMV present in lysates had a surprising range of sizes, buoyant densities, and distinct relative amounts of encapsidated RNAs. These results show that the encapsidated BMV RNAs reflect a combination of host effects on the physiochemical properties of the viral capsids and the enrichment of a subset of virions. The previously unexpected heterogeneity in BMV should influence the timing of the infection and also the host innate immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.