ArticleCirculation. Cardiovascular imaging2013
Effects of age and aerobic fitness on myocardial lipid content.
Article in Circulation. Cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Guideline
- Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome.Biomedicines · 2025Article
- Myocardial steatosis across the spectrum of human health and disease.Experimental physiology · 2024Review
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: Understanding Mechanisms by Using Noninvasive Methods.JACC. Cardiovascular imaging · 2020Review
- CEST MRI reveals a correlation between visceral fat mass and reduced myocardial creatine in obese individuals despite preserved ventricular structure and function.NMR in biomedicine · 2019Article
- Heart Failure With Preserved Ejection Fraction In Perspective.Circulation research · 2019 · on this mapReview
- Cardiac- versus diaphragm-based respiratory navigation for proton spectroscopy of the heart.Magma (New York, N.Y.) · 2019Article
- Lipolytic Rate Associated With Intramyocardial Lipid in an HIV Cohort Without Increased Lipolysis.The Journal of clinical endocrinology and metabolism · 2016Article
- Preventing heart failure: the role of physical activity.Current opinion in cardiology · 2015Review
- Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2015Article
- Positive effects of voluntary running on metabolic syndrome-related disorders in non-obese hereditary hypertriacylglycerolemic rats.PloS one · 2015Article
- Predictors of Ectopic Fat in Humans.Current obesity reports · 2014Article
- Impact of general and central adiposity on ventricular-arterial aging in women and men.JACC. Heart failure · 2014Article
- Impact of lifelong exercise "dose" on left ventricular compliance and distensibility.Journal of the American College of Cardiology · 2014Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAging and sedentary lifestyles lead to cardiac atrophy, ventricular stiffening, and impaired diastolic function. Both conditions are marked by increased adiposity, which can lead to ectopic fat deposition in nonadipocyte tissues including the myocardium. The effect of excess intramyocardial fat on cardiac function in nonobese individuals is unknown. METHODS AND
resultsCardiac lipid content was measured by magnetic resonance spectroscopy in 153 healthy nonobese subjects with varying fitness levels quantified by peak oxygen uptake during treadmill exercise. Cardiac function (echo) and left ventricular (LV) filling pressures (right heart catheterization) were measured under varying preloads. LV stiffness was calculated from a curve fit of the diastolic portion of the pressure-volume curve. The strongest clinical predictors of lipid content were body mass index (β=+0.03; 95% confidence interval, 0.001-0.06) and peak oxygen uptake (β=-0.02; 95% confidence interval, -0.03 to -0.009; R(2)=0.14; P<0.001). Subjects in the highest quintile had smaller LV end-diastolic volumes (68±13 versus 58±12 mL/m(2); P<0.01) and decreased peak early mitral annular and increased peak late mitral inflow velocities. There were no differences in LV stiffness, but a leftward shift in the pressure-volume curve suggested a less distensible ventricle with increasing myocardial lipid levels. After adjusting for age, fitness, and body mass index, echocardiographic and morphometric differences among groups were attenuated and no longer significant.
conclusionsBody mass index and fitness levels are the strongest predictors of myocardial lipid content in nonobese humans. Cardiac lipid content is associated with decreased ventricular distensibility, and it may provide a causal mechanism linking changes in LV function related to age and fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.