Evidence map›Paper›PMID 24036319›Full record

SynthesisProgress in neuro-psychopharmacology & biological psychiatry2014

Correspondence of executive function related functional and anatomical alterations in aging brain.

Xin Di, Bart Rypma, Bharat B Biswal

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Progress in neuro-psychopharmacology & biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Efficacy of transcranial alternating current stimulation on cognitive function in patients with dementia: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin DiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07101, USA. Electronic address: synge.x.d@gmail.com.
Bart Rypma
Bharat B Biswal

Funding

Functional MRI of Aging: Biophysical CharacterizationR01AG032088 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BISWAL, BHARAT BHUSAN · 2010 to 2014
$1.5M
Physiological, neural and cognitive bases of age-related working memory changeR01AG029523 · NIA · UNIVERSITY OF TEXAS DALLAS · PI RYPMA, BART · 2007 to 2010
$1.2M
NIA NIH HHS 1R01AG029523NIA NIH HHS 5R01AG032088NIA NIH HHS R01 AG029523NIA NIH HHS R01 AG032088
6 · The paper itself

Abstract

Neurocognitive aging studies have focused on age-related changes in neural activity or neural structure but few studies have focused on relationships between the two. The present study quantitatively reviewed 24 studies of age-related changes in fMRI activation across a broad spectrum of executive function tasks using activation likelihood estimation (ALE) and 22 separate studies of age-related changes in gray matter using voxel-based morphometry (VBM). Conjunction analyses between functional and structural alteration maps were constructed. Overlaps were only observed in the conjunction of dorsolateral prefrontal cortex (DLPFC) gray matter reduction and functional hyperactivation but not hypoactivation. It was not evident that the conjunctions between gray matter and activation were related to task performance. Theoretical implications of these results are discussed.

Indexed as

BrainAgedAged, 80 and overAgingExecutive FunctionFemaleHumansLikelihood FunctionsMaleNeuroimagingNeuropsychological TestsPubMedRadionuclide Imagingactivation likelihood estimationAgingALECBFcerebral blood flowcerebral-metabolic oxygen rate of oxygenCMRO(2)DLPFCdorsolateral prefrontal cortexDorsolateral prefrontal cortexEfficiencyExecutive functionfalse discovery rateFDRfMRIfull width at half maximumfunctional magnetic resonance imagingFWHMGMgray matterinferior parietal lobuleIPLMeta-analysisMNIMontreal Neurological InstitutePETPlasticitypositron emission tomographySMAsupplementary motor areaVBMventrolateral prefrontal cortexVLPFCvoxel-based morphometry

Identifiers

PMID24036319
PMCPMC3870052

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.