ArticleDevelopmental biology2013
Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- The myoblast methylome: multiple types of associations with chromatin and transcription.Epigenetics · 2025Article
- Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks.PLoS biology · 2025Article
- Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues.bioRxiv : the preprint server for biology · 2025Article
- Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation.BMC biology · 2024Article
- Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation.bioRxiv : the preprint server for biology · 2024Article
- Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer.Acta pharmaceutica Sinica. B · 2023Article
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- Somite Compartments in Amphioxus and Its Implications on the Evolution of the Vertebrate Skeletal Tissues.Frontiers in cell and developmental biology · 2021Article
- Systematized reporter assays reveal ZIC protein regulatory abilities are Subclass-specific and dependent upon transcription factor binding site context.Scientific reports · 2020Article
- Review
- Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription.Epigenetics · 2018Article
- Article
- The distribution and adipogenic potential of perivascular adipose tissue adipocyte progenitors is dependent on sexual dimorphism and vessel location.Physiological reports · 2016Article
- From pluripotency to myogenesis: a multistep process in the dish.Journal of muscle research and cell motility · 2015Review
- Novel Lethal Form of Congenital Hypopituitarism Associated With the First Recessive LHX4 Mutation.The Journal of clinical endocrinology and metabolism · 2015Article
- Chromatin signaling in muscle stem cells: interpreting the regenerative microenvironment.Frontiers in aging neuroscience · 2015Review
- Identification of Pax3 and Zic1 targets in the developing neural crest.Developmental biology · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Both Glis, the downstream effectors of hedgehog signaling, and Zic transcription factors are required for Myf5 expression in the epaxial somite. Here we demonstrate a novel synergistic interaction between members of both families and Pax3, a paired-domain transcription factor that is essential for both myogenesis and neural crest development. We show that Pax3 synergizes with both Gli2 and Zic1 in transactivating the Myf5 epaxial somite (ES) enhancer in concert with the Myf5 promoter. This synergy is dependent on conserved functional domains of the proteins, as well as on a novel homeodomain motif in the Myf5 promoter and the essential Gli motif in the ES enhancer. Importantly, overexpression of Zic1 and Pax3 in the 10T1/2 mesodermal cell model results in enrichment of these factors at the endogenous Myf5 locus and induction of Myf5 expression. In our previous work, we showed that by enhancing nuclear translocation of Gli factors, Zics provide spatiotemporal patterning for Gli family members in the epaxial induction of Myf5 expression. Our current study indicates a complementary mechanism in which association with DNA-bound Pax3 strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 in the epaxial somite.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.