Evidence map›Paper›PMID 24035916›Full record

ArticleNeuropharmacology2014

Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism.

Kelly E Bosse, Emily M Jutkiewicz, Kristin N Schultz-Kuszak, Omar S Mabrouk, Robert T Kennedy, Margaret E Gnegy, John R Traynor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kelly E BosseDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Emily M JutkiewiczDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kristin N Schultz-KuszakDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Omar S MabroukDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Robert T KennedyDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Margaret E GnegyDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
John R TraynorDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: jtraynor@umich.edu.
University of Michigan–Ann Arbor · US

Funding

POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
PHARMACOLOGY OF DOPAMINE RELEASE BY AMPHETAMINER01DA011697 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 2000 to 2016
$5.3M
SUBSTANCE ABUSE INTERDISCIPLINARY TRAINING PROGRAMT32DA007267 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 1994 to 2015
$4.5M
In vivo chemical monitoring using capillary separationsR37EB003320 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KENNEDY, ROBERT T · 2008 to 2017
$3.6M
Cellular Mechanisms in Animal Models of DepressionR01MH083754 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2011 to 2011
$386k
Opioid Signaling and Regulators of G Protein SignalingF31DA019728 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOSSE, KELLY · 2006 to 2007
$65k
NIBIB NIH HHS R37 EB003320NIDA NIH HHS F31 DA019728NIDA NIH HHS R01 DA011697NIDA NIH HHS R01 DA11697NIDA NIH HHS T32 DA007267NIDA NIH HHS T32 DA007268NIDA NIH HHS T32 DA07267NIDA NIH HHS T32 DA07268NIMH NIH HHS R01 MH083754
6 · The paper itself

Abstract

Glutamate is known to cause the release of dopamine through a Ca(2+)-sensitive mechanism that involves activation of NMDA ionotropic glutamate receptors. In the current study, we tested the hypothesis that the delta opioid agonist SNC80 acts indirectly, via the glutamatergic system, to enhance both amphetamine-stimulated dopamine efflux from striatal preparations and amphetamine-stimulated locomotor activity. SNC80 increased extracellular glutamate content, which was accompanied by a concurrent decrease in GABA levels. Inhibition of NMDA signaling with the selective antagonist MK801 blocked the enhancement of both amphetamine-induced dopamine efflux and hyperlocomotion observed with SNC80 pretreatment. Addition of exogenous glutamate also potentiated amphetamine-stimulated dopamine efflux in a Mg(2+)- and MK801-sensitive manner. After removal of Mg(2+) to relieve the ion conductance inhibition of NMDA receptors, SNC80 both elicited dopamine release alone and produced a greater enhancement of amphetamine-evoked dopamine efflux. The action of SNC80 to enhance amphetamine-evoked dopamine efflux was mimicked by the GABA(B) antagonist 2-hydroxysaclofen. These cumulative findings suggest SNC80 modulates amphetamine-stimulated dopamine efflux through an intra-striatal mechanism involving inhibition of GABA transmission leading to the local release of glutamate followed by subsequent activation of NMDA receptors.

Indexed as

AmphetamineAnalgesics, OpioidAnimalsBenzamidesCorpus StriatumDizocilpine MaleateDopamineDopamine Uptake InhibitorsDrug SynergismExcitatory Amino Acid Antagonistsgamma-Aminobutyric AcidGlutamic AcidMaleMotor ActivityPiperazinesRats4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamideAmphetamineAnalgesics, OpioidBenzamidesDizocilpine MaleateDopamineDopamine Uptake InhibitorsExcitatory Amino Acid Antagonistsgamma-Aminobutyric AcidGlutamic AcidPiperazinesReceptors, N-Methyl-D-AspartateReceptors, Opioid, deltaAmphetamineDelta opioid receptorDopamineGABAGlutamateSNC80

Identifiers

PMID24035916
PMCPMC3970824
OpenAlexW2045906754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.