Evidence map›Paper›PMID 24035895›Full record

ArticleNeuroscience letters2013

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons.

Sachin P Patil, Nhung Tran, Hirosha Geekiyanage, Li Liu, Christina Chan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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  16. Nutrients in the Prevention of Alzheimer's Disease.Oxidative medicine and cellular longevity · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sachin P PatilCellular and Biomolecular Laboratory, Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA. Electronic address: spatil@widener.edu.
Nhung Tran
Hirosha Geekiyanage
Li Liu
Christina Chan
Michigan State University · US

Funding

Develop a Dynamic Model that Incoporates Text-mining to Reconstruct NetworksR01GM079688 · NIGMS · MICHIGAN STATE UNIVERSITY · PI CHAN, CHRISTINA · 2007 to 2012
$1.2M
Maximizing siRNA Function through Mechanism-based Sequence and Vehicle DesignR01GM089866 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WALTON, STEPHEN PATRICK · 2010 to 2013
$922k
NIGMS NIH HHS R01 GM079688NIGMS NIH HHS R01GM079688NIGMS NIH HHS R01 GM089866NIGMS NIH HHS R01GM089866
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular deposits of amyloid beta (Aβ) protein and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Various studies suggest that the tau tangle pathology, which lies downstream to Aβ pathology, is essential to produce AD-associated clinical phenotype and thus treatments targeting tau pathology may prevent or delay disease progression effectively. In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons. Human epidemiological and animal data suggest potential positive effects of these polyphenols against AD. Here, primary rat cortical neurons treated with these polyphenols significantly up-regulated BAG2 levels at different concentrations, while only EGCG upregulated LAMP1 levels, although at higher concentrations. Importantly, curcumin doubled BAG2 levels at low micromolar concentrations that are clinically relevant. In addition, curcumin also downregulated levels of phosphorylated tau, which may be potentially attributed to the curcumin-induced upregulation in BAG2 levels in the neurons. The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.

Indexed as

AnimalsCatechinCerebral CortexCurcuminLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMolecular ChaperonesNeuronsPrimary Cell CultureRatsResveratrolStilbenestau ProteinsUp-RegulationBAG2 protein, ratCatechinCurcuminepigallocatechin gallateLamp1 protein, ratLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMolecular ChaperonesResveratrolStilbenestau ProteinsADADAM10a disintegrin and metalloproteinase domain 10Alzheimer's diseaseAMP-activated protein kinaseAMPKamyloid betaamyloid precursor proteinAPPAβBACE1BAG2BCL2-associated athanogene 2beta-site APP cleaving enzyme-1CurcuminEGCG(−)-epigallocatechin-3-gallatelactate dehydrogenaseLAMP1LDHlysosomal-associated membrane protein 1neurofibillary tanglesNFTsOAokadaic acidPolyphenolreactive oxygen speciesROSTau

Identifiers

PMID24035895
PMCPMC3825752
OpenAlexW1987231843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.