ArticleNeuroscience letters2013
Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo.
Article in Neuroscience letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
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- Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.Neuroscience · 2019Article
- Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.Current biology : CB · 2019Article
- Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction.Frontiers in cellular neuroscience · 2018Article
- L-Type Voltage-Gated CaCell reports · 2017Article
- Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Molecular neurodegeneration · 2017Article
- Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state.Nature neuroscience · 2016Article
- Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Tetanus toxin light chain has been used for some time as a genetically-encoded tool to inhibit neurotransmission and thereby dissect mechanisms underlying neural circuit formation and function. In addition to cleaving v-SNARE proteins involved in axonal neurotransmitter release, tetanus toxin light chain can also block activity-dependent dendritic exocytosis. The application of tetanus toxin light chain as a research tool in mammalian models, however, has been limited to a small number of cell types. Here we have induced expression of tetanus toxin light chain in a very small number of fluorescently labeled neurons in many regions of the adult mouse brain. This was achieved by crossing SLICK (single-neuron labeling with inducible cre-mediated knockout) transgenic lines with RC::Ptox mice that have Cre recombinase-controlled expression of the tetanus toxin light chain. Using this system we have examined the cell-autonomous effects of tetanus toxin light chain expression on dendritic spines in vivo. We find that dendritic spine density is reduced by 15% in tetanus toxin expressing hippocampal CA1 pyramidal cells, while spine morphology is unaltered. This effect is likely to be a consequence of inhibition of activity-dependent dendritic exocytosis and suggests that on-going plasticity-associated exocytosis is required for long-term dendritic spine maintenance in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.