ReviewAddictive behaviors2014
Pharmacological treatment of comorbid PTSD and substance use disorder: recent progress.
Review in Addictive behaviors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05840120 (PTSD Clinical Trials Review), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PTSD Clinical Trials Review: Examining Patient Experiences in PTSD Clinical Trials to Identify Influencing Factors
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Treatment for co-occurring posttraumatic stress disorder and substance use disorders among veterans and civilians: A test of causally moderated comparative effectiveness.Psychological trauma : theory, research, practice and policy · 2026Pooled it
- The Impact of Co-occurring Post-traumatic Stress Disorder and Substance Use Disorders on Craving: A Systematic Review of the Literature.Frontiers in psychiatry · 2021Pooled it
- Pharmacotherapy for anxiety and comorbid alcohol use disorders.The Cochrane database of systematic reviews · 2015Pooled it
- A Double-Blind, Randomized, Controlled Pilot Trial of N-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders.The Journal of clinical psychiatry · 2016Trial
- A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder.Alcoholism, clinical and experimental research · 2015Trial
- Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial.Alcoholism, clinical and experimental research · 2014Trial
- Post-Traumatic Stress Disorder and Alcohol Consumption: Biological Mechanisms of Stress Resilience to Subsequent Alcohol Consumption.Alcohol research : current reviews · 2026Review
- Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice.Psychopharmacology · 2024Article
- Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.Neuroscience and biobehavioral reviews · 2023Review
- Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders.Molecular brain · 2022Review
- Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention.Medical review (2021) · 2022Review
- Stress reveals a specific behavioral phenotype for opioid abuse susceptibility.Journal of the experimental analysis of behavior · 2022Article
- Mining Clinical Data for Novel Posttraumatic Stress Disorder Medications.Biological psychiatry · 2022Article
- Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Brain reward circuitry: The overlapping neurobiology of trauma and substance use disorders.World journal of psychiatry · 2021Review
- Reward Processing and Circuit Dysregulation in Posttraumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse.Addiction biology · 2020Article
- Key Clinical Interest Outcomes of Pharmaceutical Administration for Veterans With Post-Traumatic Stress Disorder Based on Pooled Evidences of 36 Randomised Controlled Trials With 2,331 Adults.Frontiers in pharmacology · 2020Review
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Previous research has identified a strong association between posttraumatic stress disorder (PTSD) and substance use disorder (SUD), necessitating the development of treatments that address both conditions. Some pharmacotherapies are effective for the treatment of PTSD and SUD alone, however; no medications have been proven to be effective for the combination of these conditions. We review the recent advances in pharmacological treatment of comorbid PTSD and SUD. A randomized clinical trial of sertraline, a serotonin reuptake inhibitor (SSRI), did not show overall efficacy for comorbid PTSD and alcohol dependence (AD), although it may have efficacy among light drinkers. Another clinical trial demonstrated the efficacy of both disulfiram and naltrexone for the treatment of AD in individuals with PTSD. A more recent clinical trial suggested that norepinephrine uptake inhibitors may also have efficacy for the treatment of comorbid PTSD and AD. In animal and preliminary human studies, brain norepinephrine and glutamate/GABA have emerged as potential treatment targets for comorbid PTSD and SUD. Noradrenergic medications that are promising for comorbid PTSD and SUD include prazosin, guanfacine, and atomoxetine. Promising glutamate/GABA medications include topiramate, memantine, acamprosate, N-acetylcysteine (NAC), and ketamine. The safety and efficacy of these medications for the treatment of PTSD and SUD need to be tested in controlled clinical trials.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.