Evidence map›Paper›PMID 24035596›Full record

ArticleJournal of neuroimmunology2013

The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis.

Russell W Read, Susan D Vogt, Scott R Barnum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Russell W ReadDepartment of Ophthalmology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Pathology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA. Electronic address: rwr@uab.edu.
Susan D Vogt
Scott R Barnum
University of Alabama at Birmingham · US

Funding

The Role of C3 and C3 receptors in Experimental Autoimmune EncephalomyelitisR01NS046032 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNUM, SCOTT R · 2004 to 2007
$1.2M
Complement inhibition in experimental autoimmune uveitisK08EY014189 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI READ, RUSSELL W · 2002 to 2006
$979k
NEI NIH HHS EY014189NEI NIH HHS K08 EY014189NINDS NIH HHS NS46032NINDS NIH HHS R01 NS046032
6 · The paper itself

Abstract

To determine if complement anaphylatoxin-mediated inflammation contributes to the development and progression of experimental autoimmune uveitis (EAU), we induced disease in wild type and complement anaphylatoxin receptor-deficient mice (C3a receptor(-/-), C5a receptor(-/-) and C3aR(-/-)/C5aR(-/-)) and evaluated the eyes three weeks post-induction. No differences in disease severity or in disease incidence were seen between wild type controls and anaphylatoxin receptor-deficient mice. Our data indicate that C3a and C5a-mediated functions are not critical to the development of EAU.

Indexed as

AnimalsDisease Models, AnimalHumansLectins, C-TypeMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicReceptor, Anaphylatoxin C5aReceptors, ComplementUveoparotid FeverCLECL1 protein, humancomplement C3a receptorLectins, C-TypeMembrane ProteinsReceptor, Anaphylatoxin C5aReceptors, ComplementAnaphylatoxinsComplementExperimental autoimmune uveoretinitis

Identifiers

PMID24035596
PMCPMC3818408
OpenAlexW2005063912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.