ArticleCurrent biology : CB2013
Fission yeast does not age under favorable conditions, but does so after stress.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Single-cell aging trajectories reveal a dynamic coupling between nuclear size and proteasome concentration.iScience · 2026Article
- Balance between asymmetric allocation and repair of somatic damage in unicellular life forms as an ancient form of r/K selection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nonlethal deleterious mutation-induced stress accelerates bacterial aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unicellular life balances asymmetric allocation and repair of somatic damage representing the origin of r/K selection.bioRxiv : the preprint server for biology · 2023Article
- Cellular senescence, rejuvenation and potential immortality.Proceedings. Biological sciences · 2022Review
- Phenotypic plasticity as a facilitator of microbial evolution.Environmental epigenetics · 2022Review
- Long-term survival of Chlamydomonas reinhardtii during conditional senescence.Archives of microbiology · 2021Article
- Cosegregation of asymmetric features during cell division.Open biology · 2021Article
- Survival of the first rather than the fittest in a Shewanella electrode biofilm.Communications biology · 2021Article
- Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation.International journal of molecular sciences · 2021Article
- Senescence in Bacteria and Its Underlying Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Article
- Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.Aging cell · 2020Article
- Protein aggregation in bacteria.FEMS microbiology reviews · 2020Review
- Bacterial ageing in the absence of external stressors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Microbial ageing and longevity.Nature reviews. Microbiology · 2019Review
- Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase.Cold Spring Harbor perspectives in biology · 2019Review
- Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness.BMC bioinformatics · 2019Article
- Cell aging preserves cellular immortality in the presence of lethal levels of damage.PLoS biology · 2019Article
- Temporal changes in cell division rate and genotoxic stress tolerance in quiescent center cells of Arabidopsis primary root apical meristem.Scientific reports · 2019Article
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10 authors.
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Abstract
backgroundMany unicellular organisms age: as time passes, they divide more slowly and ultimately die. In budding yeast, asymmetric segregation of cellular damage results in aging mother cells and rejuvenated daughters. We hypothesize that the organisms in which this asymmetry is lacking, or can be modulated, may not undergo aging.
resultsWe performed a complete pedigree analysis of microcolonies of the fission yeast Schizosaccharomyces pombe growing from a single cell. When cells were grown under favorable conditions, none of the lineages exhibited aging, which is defined as a consecutive increase in division time and increased death probability. Under favorable conditions, few cells died, and their death was random and sudden rather than following a gradual increase in division time. Cell death correlated with the inheritance of Hsp104-associated protein aggregates. After stress, the cells that inherited large aggregates aged, showing a consecutive increase in division time and an increased death probability. Their sisters, who inherited little or no aggregates, did not age.
conclusionsWe conclude that S. pombe does not age under favorable growth conditions, but does so under stress. This transition appears to be passive rather than active and results from the formation of a single large aggregate, which segregates asymmetrically at the subsequent cell division. We argue that this damage-induced asymmetric segregation has evolved to sacrifice some cells so that others may survive unscathed after severe environmental stresses.
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