ArticleBioorganic & medicinal chemistry letters2013
REDOR NMR for drug discovery.
Article in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- A Triple-Resonance NMR Strategy for the Selective Detection of NADSensors (Basel, Switzerland) · 2026Article
- Conformational Dynamics of BacteriochlorophyllThe journal of physical chemistry. B · 2025Article
- Tigliane Diterpenoids.Progress in the chemistry of organic natural products · 2024Review
- Article
- Three Decades of REDOR in Protein Science: A Solid-State NMR Technique for Distance Measurement and Spectral Editing.International journal of molecular sciences · 2023Review
- Off-resonanceJournal of biomolecular NMR · 2021Article
- Solid-state NMR spectroscopy.Nature reviews. Methods primers · 2021Article
- Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup.Biophysical journal · 2019Article
- Spectral comparisons of mammalian cells and intact organelles by solid-state NMR.Journal of structural biology · 2019Article
- Rapid measurement of long-range distances in proteins by multidimensionalJournal of biomolecular NMR · 2018Article
- REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment.ACS central science · 2018Article
- Whole Ribosome NMR: Dipolar Couplings and Contributions to Whole Cells.The journal of physical chemistry. B · 2017Article
- Article
- The Application of REDOR NMR to Understand the Conformation of Epothilone B.International journal of molecular sciences · 2017Article
- Bacterial cell wall composition and the influence of antibiotics by cell-wall and whole-cell NMR.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Closed and Semiclosed Interhelical Structures in Membrane vs Closed and Open Structures in Detergent for the Influenza Virus Hemagglutinin Fusion Peptide and Correlation of Hydrophobic Surface Area with Fusion Catalysis.Journal of the American Chemical Society · 2015Article
- Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy.Journal of the American Chemical Society · 2015Article
- Membrane protein structure from rotational diffusion.Biochimica et biophysica acta · 2015Review
- NMR structures of membrane proteins in phospholipid bilayers.Quarterly reviews of biophysics · 2014Review
- The development of solid-state NMR of membrane proteins.Biomedical spectroscopy and imagingArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Rotational-echo double-resonance (REDOR) NMR is a powerful and versatile solid-state NMR measurement that has been recruited to elucidate drug modes of action and to drive the design of new therapeutics. REDOR has been implemented to examine composition, structure, and dynamics in diverse macromolecular and whole-cell systems, including taxol-bound microtubules, enzyme-cofactor-inhibitor ternary complexes, and antibiotic-whole-cell complexes. The REDOR approach involves the integrated design of specific isotopic labeling strategies and the selection of appropriate REDOR experiments. By way of example, this digest illustrates the versatility of the REDOR approach, with an emphasis on the practical considerations of experimental design and data interpretation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.