Evidence map›Paper›PMID 24035474›Full record

ArticleUrologic oncology2014

Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.

David Goerlitz, Sania Amr, Chiranjeev Dash, Doa'a A Saleh, Mai El Daly, Mohamed Abdel-Hamid, Sherif El Kafrawy, Tamer Hifnawy, Sameera Ezzat, Mohamed A Abdel-Aziz and 4 more

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In one paragraph

Article in Urologic oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Association betweenDisease markers · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

David GoerlitzLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Sania AmrDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD.
Chiranjeev DashLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Doa'a A SalehDepartment of Public Health, Cairo University, Cairo, Egypt.
Mai El DalyDepartment of Microbiology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; National Liver Institute, Menoufiya University, Shibin El Kom, Egypt.
Mohamed Abdel-HamidDepartment of Microbiology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Department of Microbiology, Minia University, Minia, Egypt.
Sherif El KafrawyDepartment of Microbiology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; National Liver Institute, Menoufiya University, Shibin El Kom, Egypt; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Tamer HifnawyPublic Health Department, Beni Suif University, Beni Suif, Egypt.
Sameera EzzatNational Liver Institute, Menoufiya University, Shibin El Kom, Egypt.
Mohamed A Abdel-AzizDepartment of Urology, Assiut University, Assiut, Egypt.
Hussein KhaledDepartment of Medical Oncology, National Cancer Institute, Cairo, Egypt.
Yun-Ling ZhengLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Nabiel MikhailDepartment of Microbiology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Department of Urology, Assiut University, Assiut, Egypt.
Christopher A LoffredoLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC. Electronic address: cal9@georgetown.edu.
Georgetown University Medical Center · USMenoufia University · EGNational Water Research Center · EGAssiut University · EGBeni-Suef University · EGCairo University · EGChildren Cancer Hospital · EGGeorgetown University · USUniversity of Maryland, Baltimore · US

Funding

Telomere dysfunction, chromosome 9 instability and bladder cancer riskR01CA132996 · NCI · GEORGETOWN UNIVERSITY · PI ZHENG, YUN-LING · 2009 to 2013
$2.7M
Gender Differences in Bladder Cancer Risk FactorsR01CA115618 · NCI · GEORGETOWN UNIVERSITY · PI LOFFREDO, CHRISTOPHER A · 2006 to 2010
$2.2M
NCI NIH HHS R01 CA115618NCI NIH HHS R01CA115618NCI NIH HHS R01 CA132996
6 · The paper itself

Abstract

backgroundBladder cancer is the most prevalent form of cancer in men among Egyptians, for whom tobacco smoke exposure and Schistosoma haematobium (SH) infection are the major risk factors. We hypothesized that functional polymorphisms in NAD(P)H: quinone oxidoreductase 1 (NQO1) and superoxide dismutase 2 (SOD2), modulators of the effects of reactive oxidative species, can influence an individual's susceptibility to these carcinogenic exposures and hence the risk of bladder cancer.

methodsWe assessed the effects of potential interactions between functional polymorphisms in the NQO1 and SOD2 genes and exposure to smoking and SH infection on bladder cancer risk among 902 cases and 804 population-based controls in Egypt. We used unconditional logistic regression to estimate the odds ratios (OR) and confidence intervals (CI) 95%.

resultsWater pipe and cigarette smoking were more strongly associated with cancer risk among individuals with the TT genotype for SOD2 (OR [CI 95%] = 4.41 [1.86-10.42]) as compared with those with the CC genotype (OR [CI 95%] = 2.26 [0.97-6.74]). Conversely, the risk associated with SH infection was higher among the latter (OR [CI 95%] = 3.59 [2.21-5.84]) than among the former (OR [CI 95%] = 1.86 [1.33-2.60]). Polymorphisms in NQO1 genotype showed a similar pattern, but to a much lesser extent. The highest odds for having bladder cancer following SH infection were observed among individuals with the CC genotypes for both NQO1 and SOD2 (OR [CI 95%] = 4.41 [2.32-8.38]).

conclusionOur findings suggest that genetic polymorphisms in NQO1 and SOD2 play important roles in the etiology of bladder cancer by modulating the effects of known contributing factors such as smoking and SH infection.

Indexed as

Polymorphism, Single NucleotideAgedAnimalsEgyptFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHost-Parasite InteractionsHumansLogistic ModelsMaleMiddle AgedNAD(P)H Dehydrogenase (Quinone)Odds RatioRisk FactorsNAD(P)H Dehydrogenase (Quinone)NQO1 protein, humanSuperoxide DismutaseSuperoxide Dismutase 2Bladder cancerEpidemiologyNQO1SchistosomiasisSmokingSOD2

Identifiers

PMID24035474
PMCPMC3885358
OpenAlexW1996612517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.