ArticleCell reports2013
Genomic analysis of hESC pedigrees identifies de novo mutations and enables determination of the timing and origin of mutational events.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Genomic stability of human pluripotent stem cells: advances in research and screening criteria.Stem cells translational medicine · 2026Review
- Stabilization of hESCs in two distinct substates along the continuum of pluripotency.iScience · 2022Article
- iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells.BMC cancer · 2016Article
- The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines.Scientific reports · 2015Article
- Neural stem cell replacement: a possible therapy for neurodevelopmental disorders?Neural regeneration research · 2015Article
- Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in human induced pluripotent stem cells (hiPSCs) have shown that deletions and regions of loss of heterozygosity (LOH) tend to arise during reprogramming and early culture, whereas duplications more frequently occur during long-term culture. For the corresponding experiments in human embryonic stem cells (hESCs), we studied two sets of hESC lines: one including the corresponding parental DNA and the other generated from single blastomeres from four sibling embryos. Here, we show that genetic aberrations observed in hESCs can originate during preimplantation embryo development and/or early derivation. These early aberrations are mainly deletions and LOH, whereas aberrations arising during long-term culture of hESCs are more frequently duplications. Our results highlight the importance of close monitoring of genomic integrity and the development of improved methods for derivation and culture of hPSCs.
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Registered trials
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