ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2013
[Th17 cells and IL-17 are increased in patients with brain metastases from the primary lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Immune related biomarkers for cancer metastasis to the brain.Experimental hematology & oncology · 2022Review
- A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models.Acta pharmaceutica Sinica. B · 2022Article
- Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy.Immunologic research · 2021Review
- The Network of Cytokines in Brain Metastases.Cancers · 2021Review
- [Basis of Tumor Microenvironment Relevant to Immunotherapies for Brain Metastases of NSCLC].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Review
- [Role of Interleukin 17 in Lung Carcinogenesis and Lung Cancer Progression].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Review
- The Role of Interleukin-17 in Lung Cancer.Mediators of inflammation · 2016Review
- Retinoic acid-related orphan receptor C isoform 2 expression and its prognostic significance for non-small cell lung cancer.Journal of cancer research and clinical oncology · 2016Article
- Acquirement of DNA copy number variations in non-small cell lung cancer metastasis to the brain.Oncology reports · 2015Article
- The effect of proinflammatory cytokines on IL-17RA expression in NSCLC.Medical oncology (Northwood, London, England) · 2014Article
- The immune landscape of cerebrospinal fluid across brain malignancies.Neuro-oncology advancesReview
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11 authors.
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Abstract
BACKGROUND AND
objectiveTh17 cells are important T helper cells, which are characterized by their production of IL-17. Th17 cells play an important role in host defense against microbial infections, autoimmune diseases and cancer. The aim of this study is to investigate the percentage of Th17 in peripheral blood lymphocyte and the level of IL-17 in serum and cerebrospinal fluid (CSF) in patients with brain metastases from lung cancer.
methodsTwenty-two patients with brain metastases from lung cancer and 20 health controls were analyzed. The percentage of Th17 cell was detected with flow cytometry using CD3+CD4+IL-23R+ marker, the level of IL-17 was measured with ELISA method.
resultsThe percentage of Th17 cells in patients with brain metastases from lung cancer was 4.65%±0.72%, which was remarkably higher than that in controls (2.71%±0.54%, P=0.04). There was no significant difference between non-small cell lung cancer (NSCLC) patients and small cell lung cancer (SCLC) patients. Serum IL-17 was remarkably increased in patients with brain metastases from lung cancer (117.4±16.43 pg/mL vs 72.55±8.19 pg/mL, P=0.02). No significant difference of the serum IL-17 was observed between NSCLC and SCLC patients. The level of IL-17 in CSF from patients with brain metastases from lung cancer was significant higher than that from lung cancer patients without brain metastases (73.21±7.52 pg/mL vs 50.25±8.04 pg/mL, P=0.04).
conclusionsTh17 cells and IL-17 increase in patients with brain metastases from lung cancer. It may involve in the pathogenesis of brain metastases from lung cancer.
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