ArticleGenes, brain, and behavior2013
Selection for reluctance to avoid humans during the domestication of mice.
Article in Genes, brain, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Increased abundance of Limosilactobacillus reuteri in the gut of selectively bred high-tameness mice and its association with behavioural changes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness.Genes, brain, and behavior · 2024Article
- A missense mutation inScience advances · 2023Article
- Genetic dissection of behavioral traits related to successful training of drug detection dogs.Scientific reports · 2023Article
- Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice.Genome biology · 2022Article
- Efficient genome editing in wild strains of mice using the i-GONAD method.Scientific reports · 2022Article
- Searching where the treasure is: on the emergence of human companion animal partnership (HCAP).Animal cognition · 2021Review
- Combined change of behavioral traits for domestication and gene-networks in mice selectively bred for active tameness.Genes, brain, and behavior · 2021Article
- Maternal human habituation enhances sons' risk of human-caused mortality in a large carnivore, brown bears.Scientific reports · 2020Article
- Rapid behavioral assay using handling test provides breed and sex differences in tameness of chickens.Brain and behavior · 2019Article
- Article
- Measuring Active and Passive Tameness Separately in Mice.Journal of visualized experiments : JoVE · 2018Article
- Tunnel use facilitates handling of ICR mice and decreases experimental variation.The Journal of veterinary medical science · 2018Article
- A longitudinal study of phenotypic changes in early domestication of house mice.Royal Society open science · 2018Article
- Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.Scientific reports · 2017Article
- Selective breeding and selection mapping using a novel wild-derived heterogeneous stock of mice revealed two closely-linked loci for tameness.Scientific reports · 2017Article
- CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.Scientific reports · 2017Article
- Effects of Strain and Species on the Septo-Temporal Distribution of Adult Neurogenesis in Rodents.Frontiers in neuroscience · 2017Article
- Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster.BMC evolutionary biology · 2016Article
- Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes.Frontiers in neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many animal species have been domesticated over the course of human history and became tame as a result of domestication. Tameness is a behavioral characteristic with 2 potential components: (1) reluctance to avoid humans and (2) motivation to approach humans. However, the specific behavioral characteristics selected during domestication processes remain to be clarified for many species. To quantify these 2 different components of tameness separately, we established 3 behavioral tests: the 'active tame', 'passive tame' and 'stay-on-hand' tests. We subjected genetically diverse mouse strains to these tests, including 10 wild strains (BFM/2Ms, PGN2/Ms, HMI/Ms, BLG2/Ms, NJL/Ms, KJR/Ms, SWN/Ms, CHD/Ms, MSM/Ms and CAST/Ei), a fancy strain (JF1/Ms) and 6 standard laboratory strains (C3H/HeNJcl, CBA/J, BALB/cAnNCrlCrlj, DBA/2JJcl, 129(+Ter) /SvJcl and C57BL/6JJcl). To analyze the effects of domestication, these 17 strains were divided into 2 groups: domesticated strains (fancy and laboratory strains) and wild strains. Significant differences between strains were observed in all traits, and the calculated estimates of broad-sense heritability were 0.15-0.72. These results illustrate that tameness in mice is significantly influenced by genetic background. In addition, they clearly show the differences in the features of tameness in domesticated and wild strains. Most of the domesticated strains showed significantly greater reluctance to avoid humans than wild strains, whereas there was no significant difference in the level of motivation to approach humans between these 2 groups. These results might help to clarify the genetic basis of tameness in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.