Evidence map›Paper›PMID 24034345›Full record

ArticleThe Journal of allergy and clinical immunology2014

Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases.

Randi J Bertelsen, Anne Lise Brantsæter, Maria C Magnus, Margaretha Haugen, Ronny Myhre, Bo Jacobsson, Matthew P Longnecker, Helle M Meltzer, Stephanie J London

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02693028 nacompletednot on this mapstarted 2015, after this paper: background citation

Lactobacillus Reuteri Feasibility Study on Probiotic Lozenges, Probiotic Chewing Gum and Probiotic Capsules and Perinatal Microbiome Seeding During Pregnancy

TypeinterventionalSponsorSahlgrenska University HospitalRan2015 to 2018Enrolled30ConditionsPregnancyArmsProbiotic lozenges, Placebo lozenges, Probiotic capsules, Placebo capsules, Probiotic chewing gum
NCT02693041 nacompletednot on this map

Pregnancy Complications - A Probiotic Interventional Study

TypeinterventionalSponsorSahlgrenska University HospitalRan2012 to 2021Enrolled105ConditionsPreeclampsia, Preterm BirthArmsprobiotic, placebo
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Pooled it
  3. Trial
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  7. Review
  8. Article
  9. Article
  10. Impact of Exposomes on Ocular Surface Diseases.International journal of molecular sciences · 2023
    Review
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  13. Article
  14. Review
  15. Article
  16. Review
  17. Probiotics Function in Preventing Atopic Dermatitis in Children.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. S3 guideline Allergy Prevention.Allergologie select · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Randi J BertelsenDepartment of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Electronic address: randi.jacobsen.bertelsen@fhi.no.
Anne Lise BrantsæterDepartment of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.
Maria C MagnusEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.
Margaretha HaugenDepartment of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.
Ronny MyhreDepartment of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Bo JacobssonDepartment of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway; Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg, Sweden.
Matthew P LongneckerEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC.
Helle M MeltzerDepartment of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC.
Norwegian Institute of Public Health · NONational Institute of Environmental Health Sciences · USNational Institutes of Health · US

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
The Norwegian Mother And Child Study: Environmental Specimen CollectionZIAES044008 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2018
$4.3M
Intramural NIH HHS ZIA ES049019NIEHS NIH HHS N01 ES075558NINDS NIH HHS 1 UO1 NS 047537-01NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundWhether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants.

objectivesWe sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study).

methodsWe examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders.

resultsConsumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months.

conclusionsIn this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age.

Indexed as

AdultAnimalsAsthmaCattleChild, PreschoolCohort StudiesConjunctivitisDermatitis, AtopicDietary SupplementsFemaleHumansInfantInfant, NewbornMaleMaternal ExposureMilkAllergyasthmaBMIBody mass indexeczemaFFQFood frequency questionnaireMegajoulesmicrobiomeMJMoBaNorwegian Mother and Child Cohort StudyprobioticsRelative riskrhinoconjunctivitisRR

Identifiers

PMID24034345
PMCPMC3912862
OpenAlexW2062201650

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.