ArticleCell2013
A template for new drugs against Alzheimer's disease.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development.Alzheimer's & dementia (New York, N. Y.) · 2017Review
- There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS.Brain research · 2016Review
- Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue.Scientific reports · 2016Article
- Polymorphism of Amyloid Fibrils In Vivo.Angewandte Chemie (International ed. in English) · 2016Article
- Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.Acta neuropathologica · 2016Article
- Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells.Drug design, development and therapy · 2015Article
- Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.The Biochemical journal · 2014Article
- Neurodegeneration: Alzheimer's disease under strain.Nature · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Alzheimer's disease (AD) is associated with the deposition of β-amyloid (Aβ) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of Aβ fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.
Indexed as
Identifiers
24034239What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.