ArticleScandinavian journal of immunology2013
Lack of functional TSLP receptors mitigates Th2 polarization and the establishment and growth of 4T1 primary breast tumours but has different effects on tumour quantities in the lung and brain.
Article in Scandinavian journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- The correlation between single nucleotide polymorphisms of the thymic stromal lymphopoietin receptor and breast cancer in a cohort of female patients in Saudi Arabia.Environmental science and pollution research international · 2021Article
- Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression.Cells · 2021Review
- Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms.Frontiers in immunology · 2020Review
- The role of the immune system in brain metastasis.Current neurobiology · 2019Article
- Overexpression of thymic stromal lymphopoietin is correlated with poor prognosis in epithelial ovarian carcinoma.Bioscience reports · 2019Article
- Thymic stromal lymphopoietin in human pancreatic ductal adenocarcinoma: expression and prognostic significance.Oncotarget · 2018Article
- Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model.Cancer immunology, immunotherapy : CII · 2018Article
- Thymic Stromal Lymphopoietin: To Cut a Long Story Short.Cellular and molecular gastroenterology and hepatology · 2017Review
- Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior.Journal of visualized experiments : JoVE · 2016Article
- A Multifaceted Role for Myd88-Dependent Signaling in Progression of Murine Mammary Carcinoma.Breast cancer : basic and clinical research · 2016Article
- TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients.Yonago acta medica · 2015Article
- Thymic stromal lymphopoietin and cancer.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-κB signal pathways.International journal of clinical and experimental pathology · 2014Article
- Allergy-Related Diseases and Risk of Breast Cancer: The Role of Skewed Immune System on This Association.Allergy & rhinology (Providence, R.I.)Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The 4T1 mammary carcinoma cell line produces TSLP. We had hypothesized that TSLP promotes the development of a permissive environment for the growth and metastasis of primary tumour and that this is associated with a Th2-polarized antitumour immune response. We found that, in Tslpr(-/-) mice, the mean tumour diameters were smaller from days 27 to 40, and relatively fewer tumour cells were present in the lung, compared with wild-type mice. Polarization of the Th2 cytokine profile was also diminished in Tslpr(-/-) mice. These findings confirmed those reported previously by others. Here, we further show that primary tumours are established less often in Tslpr(-/-) mice and that, unexpectedly, the relative number of tumour cells in the brain is greater in Tslpr(-/-) mice compared with wild-type mice. Findings from our cytotoxicity assays show that 4T1-directed lysis is undetectable in both WT and Tslpr(-/-) mice, ruling out the possibility that altered cytotoxic responses in Tslpr(-/-) mice are responsible for the differences we observed. In a human tissue microarray, positive staining for TSLP was seen in tumour cells from breast cancer tissue, but it was also seen in normal glandular epithelial cells from normal breast tissue, which has not been shown before. Thus, our findings provide new insight into the effects of TSLP in metastatic breast cancer.
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