Evidence map›Paper›PMID 24033276›Full record

ArticleACS applied materials & interfaces2013

Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.

Nicholas Clay, Kwanghyun Baek, Artem Shkumatov, Mei-Hsiu Lai, Cartney E Smith, Max Rich, Hyunjoon Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas Clay *Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Kwanghyun Baek *Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Artem ShkumatovDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Mei-Hsiu LaiDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Cartney E SmithDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Max RichDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.
Hyunjoon KongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, United States.

Funding

Nanocells for vascular normalization therapiesR01HL109192 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2011 to 2015
$1.9M
Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI MR25CA154015 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID, NARDULLI, ANN · 2010 to 2014
$1.5M
NCI NIH HHS R25 CA154015NCI NIH HHS R25 CA154015ANHLBI NIH HHS 1R01 HL109192NHLBI NIH HHS R01 HL109192
6 · The paper itself

Abstract

This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

Indexed as

AnimalsAspartic AcidBone Marrow CellsCells, CulturedCell TrackingContrast MediaEndocytosisFerric CompoundsMagnetic Resonance ImagingMagnetite NanoparticlesMechanotransduction, CellularMesenchymal Stem CellsMicePeptidesAspartic AcidContrast MediaFerric Compoundsferric oxideMagnetite NanoparticlesPeptidespoly-DL-succinimide

Identifiers

PMID24033276
PMCPMC3872536

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.