ArticleMolecular pharmaceutics2013
Noninvasive fluorescence resonance energy transfer imaging of in vivo premature drug release from polymeric nanoparticles.
Article in Molecular pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- ACQ-FRET dual-functional near-infrared fluorescent probes for the bioimaging of nanocarriers.Asian journal of pharmaceutical sciences · 2026Article
- Precise Control of the in vivo Fate of Nanomicelles Efficiently Treats Advanced Rheumatoid Arthritis via EGFR/JNK/MMP9 Pathway.International journal of nanomedicine · 2025Article
- Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis.Journal of personalized medicine · 2023Review
- Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis.Materials today. Bio · 2023Article
- Fluorescence-Shadowing Nanoparticle Clusters for Real-Time Monitoring of Tumor Progression.Biomacromolecules · 2022Article
- Improved Core Viscosity Achieved by PDLLAPharmaceutical research · 2022Article
- FRET Ratiometric Nanoprobes for Nanoparticle Monitoring.Biosensors · 2021Review
- Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties.Pharmaceutics · 2021Article
- Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity.International journal of nanomedicine · 2021Article
- In Vitro and In Vivo Models for Evaluating the Oral Toxicity of Nanomedicines.Nanomaterials (Basel, Switzerland) · 2020Review
- Toward understanding polymer micelle stability: Density ultracentrifugation offers insight into polymer micelle stability in human fluids.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Imaging-assisted anticancer nanotherapy.Theranostics · 2020Review
- Förster Resonance Energy Transfer-Based Stability Assessment of PLGA Nanoparticles in Vitro and in Vivo.ACS applied bio materials · 2019Article
- Physicochemical Characterization of FRET-Labelled Chitosan Nanocapsules and Model Degradation Studies.Nanomaterials (Basel, Switzerland) · 2018Article
- Flow Virometry: a Powerful Tool To Functionally Characterize Viruses.Journal of virology · 2018Review
- Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release.ACS nano · 2017Article
- Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.Advanced drug delivery reviews · 2017Review
- A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood-brain barrier, and the transporting mechanism to glioma cells.International journal of nanomedicine · 2017Article
- Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery.Macromolecular bioscience · 2017Review
- Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging.Therapeutic delivery · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Understanding in vivo drug release kinetics is critical for the development of nanoparticle-based delivery systems. In this study, we developed a fluorescence resonance energy transfer (FRET) imaging approach to noninvasively monitor in vitro and in vivo cargo release from polymeric nanoparticles. The FRET donor dye (DiO or DiD) and acceptor dye (DiI or DiR) were individually encapsulated into poly(ethylene oxide)-b-polystyrene (PEO-PS) nanoparticles. When DiO (donor) nanoparticles and DiI (acceptor) nanoparticles were coincubated with cancer cells for 2 h, increased FRET signals were observed from cell membranes, suggesting rapid release of DiO and DiI to cell membranes. Similarly, increased FRET ratios were detected in nude mice after intravenous coadministration of DiD (donor) nanoparticles and DiR (acceptor) nanoparticles. In contrast, another group of nude mice i.v. administrated with DiD/DiR coloaded nanoparticles showed decreased FRET ratios. Based on the difference in FRET ratios between the two groups, in vivo DiD/DiR release half-life from PEO-PS nanoparticles was determined to be 9.2 min. In addition, it was observed that the presence of cell membranes facilitated burst release of lipophilic cargos while incorporation of oleic acid-coated iron oxide into PEO-PS nanoparticles slowed the release of DiD/DiR to cell membranes. The developed in vitro and in vivo FRET imaging techniques can be used to screening stable nanoformulations for lipophilic drug delivery.
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