ArticleChild development
How and why does the 5-HTTLPR gene moderate associations between maternal unresponsiveness and children's disruptive problems?
Article in Child development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Differential Relations of Parental Behavior to Children's Early Executive Function as a Function of Child Genotype: A Systematic Review.Clinical child and family psychology review · 2022Pooled it
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior.Development and psychopathology · 2015Trial
- Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood.Development and psychopathology · 2023Article
- Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms.Scientific reports · 2021Article
- Socioemotional Mechanisms of Children's Differential Response to the Effects of Maternal Sensitivity on Child Adjustment.Parenting, science and practice · 2021Article
- Approach-related emotion, toddlers' persistence, and negative reactions to failure.Social development (Oxford, England) · 2018Article
- Breaking cycles of risk: The mitigating role of maternal working memory in associations among socioeconomic status, early caregiving, and children's working memory.Development and psychopathology · 2017Article
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
- Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: implications for differential susceptibility.Development and psychopathology · 2015Article
- 5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This study tested the 5-HTTLPR gene as a moderator in the relation between maternal unresponsiveness and child externalizing symptoms in a disadvantaged, predominantly Black sample of two hundred and one 2-year-old children and their mothers. Using a multimethod, prospective design, structural equation model analyses indicated that maternal unresponsiveness significantly predicted increases in externalizing symptoms 2 years later only for children possessing the LL genotype. Moderation was expressed in a "for better" or "for worse" form hypothesized in differential susceptibility theory. In examining why the risk posed by maternal unresponsiveness differed across the 5-HTTLPR polymorphism, mediated moderation analyses showed that children's angry reactivity to maternal negativity partly accounted for the greater susceptibility of homozygous L carriers to variations in maternal unresponsiveness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.