ArticleEpilepsia2013
Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 163 citations in OpenAlex.
- Efficacy of delivery of care with Tele-continuous EEG in critically ill patients: a multicenter randomized controlled trial (Tele-cRCT study) study.Critical care (London, England) · 2025Trial
- Article
- Post-Traumatic Epilepsy After Mild and Moderate Traumatic Brain Injury: A Narrative Review and Development of a Clinical Decision Tool.Reports (MDPI) · 2025Review
- Multimodal neuromonitoring in the nordic countries: experiences and attitudes - a multi-institutional survey.Acta neurochirurgica · 2025Article
- Late-Onset Findings During Extended EEG Monitoring Are Rare in Critically Ill Children.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- Associations between Electroencephalographic Variables, Early Post-Traumatic Seizure Risk, and Outcomes following Pediatric Severe Traumatic Brain Injury.Journal of pediatric intensive care · 2024Article
- Utility of Electroencephalograms for Enhancing Clinical Care and Rehabilitation of Children with Acquired Brain Injury.International journal of environmental research and public health · 2024Review
- Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview.Biomedicines · 2024Review
- Neuromonitoring in Children with Traumatic Brain Injury.Neurocritical care · 2024Review
- Review of Noninvasive Neuromonitoring Modalities in Children II: EEG, qEEG.Neurocritical care · 2023Review
- The Role of Electroencephalography in the Prognostication of Clinical Outcomes in Critically Ill Children: A Review.Children (Basel, Switzerland) · 2022Review
- Current and Potential Pharmacologic Therapies for Traumatic Brain Injury.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Clinical Characteristics and Prognostic Significance of Subclinical Seizures in Focal Epilepsy: A Retrospective Study.Neurology and therapy · 2022Article
- Complex Pathophysiology of Abusive Head Trauma with Poor Neurological Outcome in Infants.Journal of Korean Neurosurgical Society · 2022Article
- Continuous Electroencephalogram and Antiseizure Medication Use in an International Pediatric Traumatic Brain Injury Population.Neurocritical care · 2022Article
- Occurrence of early epilepsy in children with traumatic brain injury: a retrospective study.World journal of pediatrics : WJP · 2022Article
- Clinical characteristics of post-traumatic epilepsy and the factors affecting the latency of PTE.BMC neurology · 2021Article
- Machine learning models to predict electroencephalographic seizures in critically ill children.Seizure · 2021Observational
- A review of seizures and epilepsy following traumatic brain injury.Journal of neurology · 2020Review
- EEG monitoring duration to identify electroencephalographic seizures in critically ill children.Neurology · 2020Observational
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15 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTraumatic brain injury (TBI) is an important cause of morbidity and mortality in children, and early posttraumatic seizures (EPTS) are a contributing factor to ongoing acute damage. Continuous video-EEG monitoring (cEEG) was utilized to assess the burden of clinical and electrographic EPTS.
methodsEighty-seven consecutive, unselected (mild - severe), acute TBI patients requiring pediatric intensive care unit (PICU) admission at two academic centers were monitored prospectively with cEEG per established clinical TBI protocols. Clinical and subclinical seizures and status epilepticus (SE, clinical and subclinical) were assessed for their relation to clinical risk factors and short-term outcome measures. KEY
findingsOf all patients, 42.5% (37/87) had seizures. Younger age (p = 0.002) and injury mechanism (abusive head trauma - AHT, p < 0.001) were significant risk factors. Subclinical seizures occurred in 16.1% (14/87), while 6.9% (6/87) had only subclinical seizures. Risk factors for subclinical seizures included younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p < 0.001). SE occurred in 18.4% (16/87) with risk factors including younger age (p < 0.001), AHT (p < 0.001), and intraaxial bleed (p = 0.002). Subclinical SE was detected in 13.8% (12/87) with significant risk factors including younger age (p < 0.001), AHT (p = 0.001), and intraaxial bleed (p = 0.004). Subclinical seizures were associated with lower discharge King's Outcome Scale for Childhood Head Injury (KOSCHI) score (p = 0.002). SE and subclinical SE were associated with increased hospital length of stay (p = 0.017 and p = 0.041, respectively) and lower hospital discharge KOSCHI (p = 0.007 and p = 0.040, respectively). SIGNIFICANCE: cEEG monitoring significantly improves detection of seizures/SE and is the only way to detect subclinical seizures/SE. cEEG may be indicated after pediatric TBI, particularly in younger children, AHT cases, and those with intraaxial blood on computerized tomography (CT).
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