ArticleHepatitis monthly2013
Hepatitis C virus (HCV) Infection Rate among Seronegative Hemodialysis Patients Screened by Two Methods; HCV Core Antigen and Polymerase Chain Reaction.
Article in Hepatitis monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of hepatitis C virus infection among hemodialysis patients in the Middle-East: A systematic review and meta-analysis.World journal of gastroenterology · 2017Pooled it
- Article
- Article
- Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort.BMC infectious diseases · 2018Article
- HCV Ag quantification as a one-step procedure in diagnosing chronic hepatitis C infection in Cameroon: the ANRS 12336 study.Journal of the International AIDS Society · 2017Article
- [Current status of the prevalence, diagnosis, and treatment of hepatitis C in patients undergoing hemodialysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- Prevalence of hepatitis C infection in Iranian hemodialysis patients: An updated systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Indian National Association for Study of the Liver (INASL) Guidance for Antiviral Therapy Against HCV Infection: Update 2016.Journal of clinical and experimental hepatology · 2016Review
- Hepatobiliary Quiz (Answers)-16 (2015).Journal of clinical and experimental hepatology · 2015Article
- Indian National Association for Study of the Liver (INASL) Guidance for Antiviral Therapy Against HCV Infection in 2015.Journal of clinical and experimental hepatology · 2015Review
- Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma.Hepatitis monthly · 2015Article
- Can HCV core ag testing replace the routine screening assays in patients on hemodialysis?Hepatitis monthly · 2014Article
- Management of hepatitis C virus infection in hemodialysis patients.World journal of hepatology · 2014Review
- Hepatitis C virus core antigen testing: role in diagnosis, disease monitoring and treatment.World journal of gastroenterology · 2014Review
- Utility of hepatitis C virus RNA as the screening test for diagnosing hepatitis C virus infection in hemodialysis patients.Journal of laboratory physiciansArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnd-stage renal disease patients on chronic hemodialysis are among high risk groups for hepatitis C virus (HCV) infection for whom routine HCV screening is recommended. Anti-HCV antibody (ab) testing may not be reliable to detect all infected cases because of the blunted ab response due to depressed immune state in these patients. Using a more reliable, cost-effective and non-complex HCV screening test may be necessary in this group of patients for case finding and management, and also for prevention of infection spread.
objectivesThe aim of this study was to find the prevalence of HCV infection in HCV ab negative hemodialysis patients by Real time PCR and total HCV core antigen (ag) test and comparing the results of the two tests. PATIENTS AND
methodsFrom a single hemodialysis center, 181 anti- HCV ab negative patients were screened by total HCV core ag using an ELISA kit. Real time PCR was used for determination of the virus and viral load quantity.
resultsAmong the 181 anti-HCV ab negative patients, 13 (7.2%) were positive for HCV core ag and 11 (6%) had detectable HCV RNA with a range of 40-336543 IU/ml by PCR. The two tests had a high measurement agreement (Kappa=0.82, P<0.001). Of the 13 patients with positive HCV core ag test results, 3 were negative for HCV RNA. Considering real time PCR for HCV RNA as the gold standard for HCV infection determination in this patient population, HCV core ag assay yielded a sensitivity of 90.9%, specificity of 98.2%, positive predictive value of 76.9% and negative predictive value of 99.4%. DISCUSSION: The rate of HCV infection among HCV ab negative hemodialysis patients was high. HCV core ag testing could be used as a sensitive method for HCV infection screening in this group of patients.
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