ReviewFrontiers in integrative neuroscience2013
Neuronal influence behind the central nervous system regulation of the immune cells.
Review in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2.Molecular neurobiology · 2025Article
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- Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System.International journal of molecular sciences · 2022Review
- Article
- CB2 Receptor in Microglia: The Guardian of Self-Control.International journal of molecular sciences · 2020Review
- Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging.Frontiers in neuroscience · 2020Review
- Neural activity regulates autoimmune diseases through the gateway reflex.Bioelectronic medicine · 2019Review
- Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity.Frontiers in molecular neuroscience · 2018Article
- Intercellular Adhesion Molecular-5 as Marker in HIV Associated Neurocognitive Disorder.Aging and disease · 2017Article
- Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia.CNS neuroscience & therapeutics · 2016Article
- Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation.Journal of neuroinflammation · 2016Article
- Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication.BioMed research international · 2016Article
- TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.Journal of neuroinflammation · 2015Article
- Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients.Acta neuropathologica communications · 2014Article
- Inflammation in neurodegenerative diseases--an update.Immunology · 2014Review
- Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease.Journal of molecular cell biology · 2014Review
- A perspective on the role of class III semaphorin signaling in central nervous system trauma.Frontiers in cellular neuroscience · 2014Review
- Beyond the borders: the gates and fences of neuroimmune interaction.Frontiers in integrative neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) has a highly specialized microenvironment, and despite being initially considered an immune privileged site, this immune status is far from absolute because it varies with age and brain topography. The brain monitors immune responses by several means that act in parallel; one pathway involves afferent nerves (vagal nerve) and the other resident cells (neurons and glia). These cell populations exert a strong role in the regulation of the immune system, favoring an immune-modulatory environment in the CNS. Neurons control glial cell and infiltrated T-cells by contact-dependent and -independent mechanisms. Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5, and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells. On the other hand, soluble neuronal factors like Sema-3A, cytokines, neurotrophins, neuropeptides, and neurotransmitters attenuate microglial and/or T-cell activation. In this review, we focused on all known mechanism driven only by neurons in order to control the local immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.