ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2008
In vitro synergistic activity of antibiotic combinations against Brucella melitensis using E-test methodology.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- AR-12 Has a Bactericidal Activity and a Synergistic Effect with Gentamicin against Group AInternational journal of molecular sciences · 2021Article
- Investigation of antibiotic susceptibilities of Brucella Strains isolated from various clinical samples in eastern Turkey.European journal of medical research · 2021Article
- Effect of Medium pH on Antibiotic Activity against Syrian Brucella spp. Isolates.Iranian journal of medical sciences · 2013Article
- Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Antimicrobial susceptibilities of Brucella isolates from various clinical specimens.International journal of medical sciences · 2011Article
- Brucella melitensis infection in total knee arthroplasty: a case report.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2010Article
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Authors and funding
4 authors.
Funding
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Abstract
The treatment of brucellosis is still problematic, because of high rates of treatment failure or relapses. As the microorganism is an intracellular pathogen, treatment requires combined regimens. However, limited existing data on in vitro combinations are avaliable for Brucellae. The aim of this study was to investigate the in vitro efficacy of various traditional and new antibiotic combinations against 16 Brucella melitensis strains. The combination effect of antimicrobial agents was evaluated by E-test synergy method to obtain a fractional inhibitory concentration (FIC) index. Co-Trimoxazole (SXT) and moxifloxocin (MXF) exhibited the lowest MIC, while Rifampin (RIF) had the highest MIC in the study. Combinations with RIF showed the best synergistic activity (100% of RIF-tetracycline (TET), and 87.5% of RIF-SXT). Synergistic activity was also detected at seven (43.7%) of ciprofloxocin (CIP)-SXT, four (25%) of TET-MXF, and two (12.5%) of TET-SXT combinations. The combinations that demonstrated additivity were TET-SXT, CIP-SXT and TET-MXF. Antagonism was observed only with the TET-Streptomycin (STR) combination in three strains (18.8%). Further work including randomized controlled clinical trials is required to fully evaluate the usefulness of these data.
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