ArticleYonago acta medica2013
Lymphatic Vessel Density and Vascular Endothelial Growth Factor Expression in Squamous Cell Carcinomas of Lip and Oral Cavity: A Clinicopathological Analysis with Immunohistochemistry Using Antibodies to D2-40, VEGF-C and VEGF-D.
Article in Yonago acta medica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Tumor hypoxia and role of hypoxia-inducible factor in oral cancer.World journal of surgical oncology · 2024Review
- Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma.Journal of personalized medicine · 2023Review
- Immunohistochemical assessment of Eph/ephrin expression in oral squamous cell carcinoma and precursor lesions.Odontology · 2020Article
- The siRNA silencing of DcR3 expression induces Fas ligand-mediated apoptosis in HepG2 cells.Experimental and therapeutic medicine · 2018Article
- Low Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2018Article
- Apocrine Adenocarcinoma Occurring on the Chin.Yonago acta medica · 2017Article
- Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C Expression and Lymph Node Metastasis.International journal of dentistry · 2017Article
- Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue.Oncology reports · 2016Article
- Current relevance of hypoxia in head and neck cancer.Oncotarget · 2016Review
- Vascular endothelial growth factor expression and vascular density in oral squamous cell carcinoma (OSCC): A study on clinical and histopathologic significance.Medical journal of the Islamic Republic of Iran · 2016Article
- Article
- Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- Squamous cell carcinoma of the oral cavity and circulating tumour cells.World journal of clinical oncology · 2014Review
- Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma (SCC) of the oral region often metastasizes to the cervical lymph nodes. To investigate whether the risk of cervical lymph node metastasis are predictable through lymphatic vessel density (LVD) and vascular endothelial growth factor (VEGF) expression, we assessed the relationship between LVD and clinicopathological parameters, and VEGF expression in SCC of the oral region.
methodsThe subjects were 109 patients with SCC of the oral region including the lip. Clinicopathological parameters examined for the association with LVD in a peritumoral hot spot were lymph node metastasis, histological grade and disease stage. The association with VEGF expression was similarly studied. LVD was detected by immunohistochemistry using D2-40.
resultsLVD was significantly higher in lip cancer than in other oral tumors (P < 0.0001), while there were no significant differences of LVD among other cancers of the oral cavity. LVD tended to decrease with disease progression, increase of tumor size and increase of metastatic lymph node size. Eighty-four of 109 tumors were positive for VEGF-C or D. VEGF-C-positive tumor lesions were also positive for VEGF-D. Significantly higher levels of VEGF-C and D expressions were associated with large size of lymph node metastases (P = 0.02).
conclusionSCC of the oral region including the lip that produces VEGF-C and D is significantly more likely to cause cervical lymph node metastasis. LVD in a peritumoral hot spot does not directly indicate the risk of cervical lymph node metastasis, but instead may reflect lymphangiogenesis due to VEGF together with loss of lymphatic vessels through tumor growth and progression.
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Identifiers
24031149PMC3760494W2135583172What OpenQuestion holds
Registered trials
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