ArticleYonago acta medica2013
Radiation-induced microbleeds after cranial irradiation: evaluation by phase-sensitive magnetic resonance imaging with 3.0 tesla.
Article in Yonago acta medica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of Cerebrovascular Events Among Childhood and Adolescent Patients Receiving Cranial Radiation Therapy: A PENTEC Normal Tissue Outcomes Comprehensive Review.International journal of radiation oncology, biology, physics · 2024Pooled it
- Total body irradiation is associated with increased burden of cerebral microbleeds in haematopoietic stem cell transplant recipients.British journal of haematology · 2026Article
- A study method using early dynamic acquisition of [EJNMMI research · 2024Article
- Spatial distribution of cerebral microbleeds and FLAIR hyperintensities on follow-up MRI after radiotherapy for lower grade glioma.Research in diagnostic and interventional imaging · 2023Article
- Evaluation of normal-appearing white matter with perfusion and diffusion MRI in patients with treated glioblastoma.Magma (New York, N.Y.) · 2022Article
- Research progress on mechanism and imaging of temporal lobe injury induced by radiotherapy for head and neck cancer.European radiology · 2022Review
- Article
- Non-Human Primates Receiving High-Dose Total-Body Irradiation are at Risk of Developing Cerebrovascular Injury Years Postirradiation.Radiation research · 2020Article
- Cavernous angiomas: deconstructing a neurosurgical disease.Journal of neurosurgery · 2019Review
- Initial Investigation into Microbleeds and White Matter Signal Changes following Radiotherapy for Low-Grade and Benign Brain Tumors Using Ultra-High-Field MRI Techniques.AJNR. American journal of neuroradiology · 2017Article
- Relationship between radiation dose and microbleed formation in patients with malignant glioma.Radiation oncology (London, England) · 2017Article
- Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients.Neurology · 2017Article
- Distinct Expression of Various Angiogenesis Factors in Mice Brain After Whole-Brain Irradiation by X-ray.Neurochemical research · 2017Article
- A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.Journal of neuro-oncology · 2016Article
- Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla.Journal of magnetic resonance imaging : JMRI · 2015Article
- Brain radiation-related black dots on susceptibility-weighted imaging.The neuroradiology journal · 2014Article
- Secondary brain tumors after cranial radiation therapy: A single-institution study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough there are many reports regarding radiation-induced microbleeds, its frequency, relation to dose and latency after radiation are not fully elucidated. The purpose of this study was to evaluate the frequency, latency, patient factors and dose relation of radiation-induced microbleeds after cranial irradiation using phase-sensitive magnetic resonance imaging (PSI) at 3.0 T.
methodsRetrospective evaluation of 34 patients (age range, 13-78 years; mean, 49 years; follow-up period, 3-169 months; mean 29 months) who had undergone cranial irradiation using magnetic resonance (MR) imaging including PSI was performed. Twenty-three patients received high-dose irradiation (44-60 Gy), and 11 patients received 24-30 Gy whole brain irradiation. When microbleeds were detected on MR imaging in these high-dose irradiation patients, dose distribution maps were reproduced by reviewing the clinical records. Then the irradiated areas were divided into 6 radiation-dose classes: regions > 55 Gy, 45-55 Gy, 35-45 Gy, 25-35 Gy, 15-25 Gy and 5-15 Gy. The frequency of microbleeds in each radiation-dose class was analyzed.
resultsMicrobleeds were detected in 7 (21%) of 34 patients on T2-weighted imaging, whereas they were detected in 16 (47%) of the 34 patients on PSIs. The frequency of microbleeds was higher than previously reported. The latency of radiation-induced microbleeds after radiation was 3 months to 9 years (mean, 33 months). In high-dose irradiation patients, the frequency of microbleeds significantly was associated with radiation dose. There were no foci that were observed in regions that had received < 25 Gy.
conclusionRadiation-induced microbleeds occurred more frequently in the present study than has been previously reported. PSI can be used to detect these vascular changes earlier than other conventional MR imaging techniques.
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24031146PMC3760491What OpenQuestion holds
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