ArticleYonago acta medica2011
Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats.
Article in Yonago acta medica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer.BMC complementary and alternative medicine · 2016Trial
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- Review of natural compounds for potential psoriasis treatment.Inflammopharmacology · 2023Review
- Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-κB pathways.Heliyon · 2022Article
- Kampo medicines for supportive care of patients with cancer: A brief review.Integrative medicine research · 2022Review
- Gastroprotective, hepatoprotective, and nephroprotective effects of thymol against the adverse effects of acetylsalicylic acid in rats: Biochemical and histopathological studies.Saudi journal of biological sciences · 2022Article
- Ameliorative effects of ribes rubrum oil against gastric ulcers caused by indomethacin in experimental models.Saudi journal of biological sciences · 2022Article
- Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats.Nutrition & metabolism · 2021Article
- Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats.Molecules (Basel, Switzerland) · 2020Article
- Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats.Medicina (Kaunas, Lithuania) · 2019Article
- Effects of shokyo (PeerJ · 2019Article
- Ginger and Testosterone.Biomolecules · 2018Review
- Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves.BMC complementary and alternative medicine · 2018Article
- Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer.Scientific reports · 2017Article
- ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Review
- Studies on Shokyo, Kanzo, and Keihi in Kakkonto Medicine on Prostaglandin EInternational scholarly research notices · 2016Article
- Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.Journal of natural medicines · 2013Article
- Protective Effects of Methanol Extract ofDose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the mechanism underlying the protective effects of ginger against gastric damage induced by aspirin in rats. Gastric mucosal lesions were produced by orally administering 200 mg/kg aspirin suspended in 1% carboxymethylcellulose solution to pyloric-ligated male Wistar rats. Ginger powder (200 mg/kg) markedly reduced the aspirin-induced gastric hemorrhagic ulcer area. The total acidity of gastric juice was not significantly influenced by aspirin or ginger. Ginger powder did not affect the aspirin-induced reduction in mucosal prostaglandin E2 (PGE2) content; however, it did ameliorate the aspirin-induced increases in mucosal activity of the inducible form of NO synthase (iNOS) and plasma tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels. In the next experiment, high and low doses of 6-gingerol and 6-shogaol were used instead of ginger powder in the same experimental model to examine their roles in the anti-ulcer mechanism of ginger. Both 6-gingerol and 6-shogaol reduced aspirin induced ulcer formation, mucosal iNOS and plasma TNF-α and IL-1β levels. In conclusion, ginger powder prevents the aspirin induced gastric ulcer formation by reducing mucosal iNOS activity and the plasma levels of inflammatory cytokines but does not affect gastric juice or acid production or mucosal PGE2 content. This protective effect of ginger powder against gastric ulcers may be attributable to both gingerol and shogaol.
Indexed as
Identifiers
24031124PMC3763798W2154819267What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.