ArticleThe Journal of clinical endocrinology and metabolism2013
Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00209235 (Natural History Study of Albright Hereditary Osteodystrophy), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Natural History Study of Albright Hereditary Osteodystrophy: Includes Substudies on Effects of Growth Hormone in Patients With Pseudohypoparathyroidism Type 1A and Cognitive & Behavioral Studies in Albright Hereditary Osteodystrophy
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a.Hormone research in paediatrics · 2015Trial
- Variability of endocrine findings with age and clinical severity in the long-term follow-up of pseudohypoparathyroidism: evidence of TRH resistance with central hypothyroidism.Frontiers in endocrinology · 2026Article
- Ectopic parathyroid adenoma: successful localization with 18F-fluorocholine PET/CT and parathyroid venous sampling in two cases.BMC endocrine disorders · 2025Article
- Natural History of Hyperphagia in Patients with Pseudohypoparathyroidism.Journal of clinical medicine · 2025Article
- Review
- Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients.Orphanet journal of rare diseases · 2023Article
- Neonatal and Early Infancy Features of Patients With Inactivating PTH/PTHrP Signaling Disorders/Pseudohypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2023Article
- Parathyroid diseases and metabolic syndrome.Journal of endocrinological investigation · 2023Review
- Albright hereditary osteodystrophy: Delay in the diagnosis of a rare disorder due to restricted medical services.Clinical case reports · 2023Article
- Resting Energy Expenditure and Body Composition in Children and Adolescents With Genetic, Hypothalamic, Medication-Induced or Multifactorial Severe Obesity.Frontiers in endocrinology · 2022Observational
- Pseudohypoparathyroidism: application of the Italian common healthcare-pathway for a homogeneous clinical approach and a shared follow up.Italian journal of pediatrics · 2021Article
- Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders: An Updated Practical Tool for Physicians and Patients.Hormone research in paediatrics · 2020Review
- Management of pseudohypoparathyroidism.Current opinion in pediatrics · 2019Review
- GMolecular metabolism · 2019Article
- Pseudohypoparathyroidism.Endocrinology and metabolism clinics of North America · 2018Review
- Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Article
- Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.Nature reviews. Endocrinology · 2018Review
- The stimulatory G protein GThe Journal of biological chemistry · 2018Article
- Obstructive Sleep Apnea and Otolaryngologic Manifestations in Children with Pseudohypoparathyroidism.Hormone research in paediatrics · 2018Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
contextDisruption of the Gsα maternal allele leads to severe obesity and insulin resistance in mice and early-onset obesity in patients with pseudohypoparathyroidism (PHP) type 1a. However, insulin resistance and glucose metabolism have not been systematically characterized in patients with PHP1a. OBJECTIVE, DESIGN, AND
settingIn a cross-sectional, case-control study, we examined insulin sensitivity, β-cell function, energy expenditure (EE), and sympathetic nervous system activity in adults with PHP1a. STUDY
participantsPHP1a patients (n = 8) and healthy control subjects (n = 24) matched for age (41 ± 7 vs 41 ± 7 years [mean ± SD]), gender, and percent body fat.
methodsInsulin sensitivity (SI), acute insulin response to glucose, and disposition index were assessed during a frequently sampled iv glucose tolerance test. Oral glucose insulin sensitivity (OGIS) was measured during a mixed meal. EE was measured using whole-room indirect calorimetry. Body composition was assessed via dual-energy x-ray absorptiometry and sympathetic nervous system activity by measuring 24-hour urinary catecholamine concentrations.
resultsPHP1a patients were less insulin-sensitive than their matched controls based upon SI and OGIS. Nondiabetic PHP1a patients tended to have a lower SI (P = .09) and reduced OGIS (P = .03). Disposition index, a composite measure of β-cell function, also tended to be lower in patients (P = .07). Total caloric intake, resting EE, total EE, meal-induced thermogenesis, and 24-hour urinary catecholamine concentrations were not significantly different between the groups.
conclusionsAdults with PHP-1a have reduced insulin sensitivity compared with their matched controls that may contribute to the pathogenesis of glucose intolerance and diabetes in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.