ReviewInternational journal of environmental research and public health2013
Epigenetic findings in autism: new perspectives for therapy.
Review in International journal of environmental research and public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Environmental risk factors for autism spectrum disorders.Der Nervenarzt · 2016Pooled it
- Mitochondrial-Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance.Molecular neurobiology · 2026Review
- Review
- Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.Translational psychiatry · 2025Article
- Available Treatments for Autism Spectrum Disorder: From Old Strategies to New Options.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Article
- Re-emerging concepts of immune dysregulation in autism spectrum disorders.Frontiers in psychiatry · 2022Review
- Editorial: Antioxidants in Autism Spectrum Disorders.Frontiers in psychiatry · 2022Article
- Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder.International journal of molecular sciences · 2021Review
- Stem Cell-Derived Exosomes in Autism Spectrum Disorder.International journal of environmental research and public health · 2020Review
- The many meanings of autism: conceptual and ethical reflections.Developmental medicine and child neurology · 2019Review
- Cellular therapy for autism spectrum disorder: a step forward to the optimal treatments.Annals of translational medicine · 2019Article
- Speech-Stimulating Substances in Autism Spectrum Disorders.Behavioral sciences (Basel, Switzerland) · 2019Review
- Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?Biomolecules · 2018Review
- Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2018Review
- Moderating effect of mode of delivery on the genetics of intelligence: Explorative genome-wide analyses in ALSPAC.Brain and behavior · 2018Article
- Endocrine Disruptors and Autism Spectrum Disorder in Pregnancy: A Review and Evaluation of the Quality of the Epidemiological Evidence.Children (Basel, Switzerland) · 2018Review
- Alterations in the MicroRNA of the Blood of Autism Spectrum Disorder Patients: Effects on Epigenetic Regulation and Potential Biomarkers.Behavioral sciences (Basel, Switzerland) · 2018Article
- Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, communications, restricted interests, and repetitive stereotypic behaviors. Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. However, accumulating evidence points to the involvement of epigenetic modifications as foundational in creating ASD pathophysiology. Epigenetic modifications or the alteration of DNA transcription via variations in DNA methylation and histone modifications but without alterations in the DNA sequence, affect gene regulation. These alterations in gene expression, obtained through DNA methylation and/or histone modifications, result from transcriptional regulatory influences of environmental factors, such as nutritional deficiencies, various toxicants, immunological effects, and pharmaceuticals. As such these effects are epigenetic regulators which determine the final biochemistry and physiology of the individual. In contrast to psychopharmacological interventions, bettering our understanding of how these gene-environmental interactions create autistic symptoms should facilitate the development of therapeutic targeting of gene expression for ASD biomedical care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.